Genetics of Haemochromatosis

  • M. Worwood
  • M. T. Dorak
  • R. Raha-Chowdhury
  • C. Darke
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 356)

Abstract

Haemochromatosis (HFE) was first described in the 19th century and the name was given to the disorder by von Recklinghausen in 1889. Sheldon (1935) reviewed more than 300 published cases and made many proposals about the nature of the disorder as well as suggesting that it was inherited. In 1955 Finch and Finch reviewed another 787 cases. Although the idea of haemochromatosis as an inherited disorder has received continuous support, MacDonald (1964) described haemochromatosis as “two conditions which when they occur together make up the disease but which are not causally related: iron excess and cirrhosis”.

Keywords

Yeast Artificial Chromosome Hereditary Hemochromatosis Ferritin Gene Anonymous Marker Hemochromatosis Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • M. Worwood
    • 1
  • M. T. Dorak
    • 1
  • R. Raha-Chowdhury
    • 1
  • C. Darke
    • 2
  1. 1.Department of HaematologyUniversity of Wales College of MedicineCardiffUK
  2. 2.Welsh Regional Transfusion CentreRhydlafar,Cardiff, WalesUK

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