Walter Landauer — The Man and his Work

  • Hugh Clark
  • Louis J. Pierro

Abstract

In a span of almost 60 years, Walter Landauer made notable contributions to the fields of genetics, developmental physiology and teratology. In the pages which follow we shall attempt to document the substance and merit of these contributions and to provide an understanding of the person who made them. Walter Landauer was opportunistic, orthodox and bold in his science, committed to truth, often obscured by complexities of genetic data and poorly understood biochemistry. From his early days as a student, he was concerned about economic inequities and social injustice and about a social system that failed to elicit the full potential of all its members.

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References

  1. Argraves, W. S., McKeown-Longo, P. J., and Goetinck, P. F. 1981. Absence of proteoglycan core protein in the cartilage mutant nanomelia. FEBS Letters 131: 265–268.PubMedGoogle Scholar
  2. Ariens, E. J. 1954. Affinity and intrinsic activity in the theory of competitive inhibition. Problems and theory. Arch, Int. Pharmacodyn. Ther. 99: 32–49.Google Scholar
  3. Ariens, E. J. 1964. Molecular Pharmacology. Academic Press, New York and London.Google Scholar
  4. Benedict, F. G., Landauer, W., and Fox, E. L. 1932. The physiology of normal and Frizzle fowl, with special reference to the basal metabolism. Storrs Agricultural Experiment Station Bulletin 177: 13–101.Google Scholar
  5. Boas, E. P., and Landauer, W. 1933. The effect of elevated metabolism on the hearts of Frizzle fowl. Am. J. Med. Sci. 185: 654–664.Google Scholar
  6. Boas, E. P., and Landauer, W. 1934. The effect of elevated metabolism on the heart of Frizzle fowl. II. Increased ratio of heart to body weight. Am. J. Med. Sci. 188: 359–364.Google Scholar
  7. Chang, T. K. 1949. Skeletal growth in Ancon sheep. Growth. 13: 221–267.PubMedGoogle Scholar
  8. Crew, F. A. E. 1925. Animal Genetics. Oliver and Boyd, Edinburgh.Google Scholar
  9. Cutler, I. E. 1925. Reptilian fowls. J. Hered. 16: 352–356.Google Scholar
  10. Danforth, C. H. 1932. Artificial and hereditary suppression of sacral vertebrae in the fowl. Proc. Soc. Exp. Biol. Med. 30: 143–145.Google Scholar
  11. Davenport, C. B. 1906. Inheritance in Poultry. Publications of the Carnegie Institution of Washington No. 52.Google Scholar
  12. David, P. R. 1936. Studies on the Creeper fowl. X. A study of the mode of action of a lethal factor by explantation methods. Roux Arch. Entwichmech. 135: 521–551.Google Scholar
  13. DeFranciscis, P., and Landauer, W. 1959. Effect of amniotic fluid on inhibition of growth by cortisone in chicken embryos. Nature 183: 617–618.Google Scholar
  14. Dunn, L. C. 1925. The inheritance of rumplessness in the domestic fowl. J. Hered. 16: 127–134.Google Scholar
  15. Dunn, L. C. 1927. The occurrence of chondrodystrophy in chick embryos. II. The genetic evidence. Roux Arch. Entwickmech. 110: 341–365.Google Scholar
  16. Dunn, L. C., and Landauer, W. 1934. The genetics of the rumpless fowl with evidence of a case of changing dominance. J. Genet. 29: 217–243.Google Scholar
  17. Dunn, L. C., and Landauer, W. 1936. Further data on genetic modification of rumplessness in the fowl. J. Genet. 33: 401–405.Google Scholar
  18. Elmer, W. A. and Pierro, L. J. 1964. The Creeper trait in chickens and growth of tibiotarsi in vitro. Am. Zool. 4: 1404.Google Scholar
  19. Elmer, W. A. 1968a. Experimental analysis of the Creeper condition in chickens. Effect of embryo extract on elongation, protein content, and incorporation of amino acids by cartilaginous tibiotarsi. Dev. Biol. 18: 76–92.PubMedGoogle Scholar
  20. Elmer, W. A. 1968b. In vitro and in situ analyses of the inhibitory effect of Creeper tissues. J. Exp. Zool. 169: 381–390.PubMedGoogle Scholar
  21. Fell, H. B., and Landauer, W. 1935. Experiments on skeletal growth and development in vitro in relation to the problem of avian phokomelia. Proc. Roy. Soc. London B 118: 133–154.Google Scholar
  22. Goetinck, P. F., Lever-Fisher, P. L., McKeown-Longo, P. J., Quinter, M. I., Sawyer, L. M., Sparks, K. J., and Argraves, W. S. 1981. Chondrogenesis in Normal and Mutant Avian Embryos. Chapter in: Proc. 39th Symp. Soc. Devel. Biol. Alan R. Liss, Inc. N. Y.Google Scholar
  23. Goldschmidt, R. B. 1935. Gen und Ausseneigenschaft. (Untersuchungen an Drosophila) I. II. Z. indukt. Abst. u. Vererb. 69: 38–131 (cited by Landauer, 1957a).Google Scholar
  24. Goldschmidt, R. B. 1957. Problematics of the phenomenon of phenocopy. Jour. Madras Univ. B 27: 17–24 (cited by Landauer, 1958).Google Scholar
  25. Goldschmidt, R. B., and Piternick, L. K. 1957a. The genetic background of chemically induced phenocopies in Drosophila. J. Exp. Zool. 135: 127–202.PubMedGoogle Scholar
  26. Goldschmidt, R. B., and Piternick, L. K. 1957b. The genetic background of chemically induced phenocopies in Drosophila. II. J. Exp. Zool. 136: 201–228.PubMedGoogle Scholar
  27. Gumbel, E. J., and Landauer, W. 1924. Statistische Untersuchungen über Korrelation and Symmetrie bei Echinodermenpluteis. Roux Archiv Entwickmech 101: 62–91.Google Scholar
  28. Hamburger, V., and Waugh, M. 1940. The primary development of the skeleton in nerveless and poorly innervated limb transplants of chick embryos. Physiol. Zool. 13: 367–380.Google Scholar
  29. Harland, S. C. 1939. The Genetics of Cotton. London (Jonathan Cape) (cited by Landauer, 1948c).Google Scholar
  30. Kieny, M. 1962. Action de diverses fractions de l’extract d’embryon Creeper sur la croissance de tibiotarses normaux en culture in vitro. Arch. d’Anal Microscop. et de Morph. Exp. 51: 577–586.Google Scholar
  31. Krim, S. 1960. Structure of Frizzle mutant feather keratin. J. Mol Biol. 2: 247–249.Google Scholar
  32. Lamoreux, W. F. 1942. Hereditary chondrodystrophy in the fowl. J. Hered. 33: 275–283.Google Scholar
  33. Landauer, W. 1922. Untersuchungen uber die Verschiebung der Vererbungsrichtung bei Echinodermen-Bastardlarven unter dem Einfluss von Ammoniak. Roux Archiv Entwicklungsmech. 52: 1–94.Google Scholar
  34. Landauer, W. 1924. Laceration, Knospung und Heteromorphose bei Actinia equina L. Z Morph. Okol. Tiere. 3: 177–187.Google Scholar
  35. Landauer, W. 1925a. On the hair direction in mammals. J. Mamm. 6: 217–232.Google Scholar
  36. Landauer, W. 1925b. Bemerkungen zu Ludwigs Hypothese der Morphogenese des Haarstrichs. Zool Am. 64: 235–244.Google Scholar
  37. Landauer, W. 1925c. Der spezifische Erreger der Zellteilung. Biol Gen. 1: 674–694.Google Scholar
  38. Landauer, W. 1925d. Ergebnisse in der Erbanalyse der Behornung von Rind, Schaf und Ziege. Z indukt. Abs. u Vererb. 39: 294–322.Google Scholar
  39. Landauer, W. 1925e. Bemerkungen über Variation, Symmetrie und Korrelation bei Echinoideenpluteis. Z indukt. Abs. u Vererb. 38: 62–71.Google Scholar
  40. Landauer, W. 1926a. Zur Regeneration der Aktiniarien. Z Morph. Okol. 6: 586–587.Google Scholar
  41. Landauer, W. 1926b. Die Vererbung von Haar-und Hautmerkmalen, ausschliesslich Farbung und Zeichnung, mit Berucksichtigung von Rassedifferenzierung und Deszendenz. Z indukt. Abs. u Vererb. 42: 113–226.Google Scholar
  42. Landauer, W. 1927. Untersuchungen über Chondrodystrophie. I. Allgemeine Erscheinungen und Skelett chondrodystrophischer Hühnerembryonen. Roux Arch Entwicklungsmech. 110: 195–278.Google Scholar
  43. Landauer, W. 1930. Linkage Tests in Poultry. I. Biol. Gen. 8: 219–226.Google Scholar
  44. Landauer, W. 1931. Untersuchungen uber das Krüperhuhn. II. Morphologie und Histologie des Skelets, insbesondere des Skelets der langen Extremitätenknochen. Z. mikro anat. Forschung 25: 115–180.Google Scholar
  45. Landauer, W. 1932a. Studies on the Creeper fowl. III. The early development and lethal expression of homozygous Creeper embryos. J. Genet. 25: 367–394.Google Scholar
  46. Landauer, W. 1932b. Studies on the Creeper fowl. V. The linkage of the genes for Creeper and single-comb. J. Genet. 26: 285–290.Google Scholar
  47. Landauer, W. 1933. A gene modifying frizzling in the fowl. J. Hered. 24: 153–156.Google Scholar
  48. Landauer, W. 1934. Studies on the Creeper fowl. VI. Skeletal growth of Creeper chickens, with special reference to growth of the long bones. Storrs Agricultural Experiment Station Bulletin 193: 1–79.Google Scholar
  49. Landauer, W. 1937. Loss of body heat and disease. Am. J. Med. Sci. 194: 667–674.Google Scholar
  50. Landauer, W. 1941. A semi-lethal mutation in fowl, affecting length of the upper beak and of the long bones. Genetics 26: 426–439.PubMedGoogle Scholar
  51. Landauer, W. 1942. Form and function in Frizzle fowl: The interaction of hereditary potentialities and environmental temperature. Biological Symposia 6: 127–166.Google Scholar
  52. Landauer, W. 1945a. Recessive rumplessness of fowl with kypho-scoliosis and supernumerary ribs. Genetics 30: 403–428.PubMedGoogle Scholar
  53. Landauer, W. 1945b. Rumplessness of chicken embryos produced by the injection of insulin and other chemicals. J. Exp. Zool. 98: 65–77.Google Scholar
  54. Landauer, W. 1945c. Shall we lose or keep our plant and animal stocks. Science. 101: 497–499.PubMedGoogle Scholar
  55. Landauer, W. 1946. The results of selection against expression of the “short upper beak” mutation in fowl. Amer. Nat. 80: 490–494.Google Scholar
  56. Landauer, W. 1947a. Insulin-induced abnormalities of beak, extremities and eyes in chickens. J. Exp. Zool. 105: 145–172.PubMedGoogle Scholar
  57. Landauer, W. 1947b. Potentiating effects of adrenal cortical extract on insulin-induced abnormalities of chick development. Endocrinology 41: 489–493.PubMedGoogle Scholar
  58. Landauer, W. 1948a. The phenotypic modification of hereditary polydactylism of fowl by selection and by insulin. Genetics 33: 133–157.PubMedGoogle Scholar
  59. Landauer, W. 1948b. The effect of nicotinamide and α-ketoglutaric acid on the teratogenic action of insulin. J. Exp. Zool. 109: 283–290.PubMedGoogle Scholar
  60. Landauer, W. 1948c. Hereditary abnormalities and their chemically-induced phenocopies. Growth Symposium 12: 171–200.Google Scholar
  61. Landauer, W. 1949. Le problème de l’électivité dans les expériences de tératogenèse biochimique. Arch. d’Anal microsc. et Morph exp. 38: 184–189.Google Scholar
  62. Landauer, W. 1952a. The genetic control of normal development in the chicken embryo. Annals N. Y. Acad. Sci. 55: 172–176.Google Scholar
  63. Landauer, W. 1952b. Malformations of chick embryos produced by boric acid and the probable role of riboflavin in their origin. J. Exp. Zool 120: 469–508.Google Scholar
  64. Landauer, W. 1953a. On teratogenic effects of pilocarpine in chick development. J. Exp. Zool. 122: 469–483.Google Scholar
  65. Landauer, W. 1953b. Complex formation and chemical specificity of boric acid in production of chicken embryo malformations. Proc. Soc. exp. Biol. Med. 82: 633–636.PubMedGoogle Scholar
  66. Landauer, W. 1954. On the chemical production of developmental abnormalities and of phenocopies in chicken embryos. J. Cell. Comp. Physiol. 43: 261–305 (Supp).Google Scholar
  67. Landauer, W. 1956a. Cyclopia and related defects as a lethal mutation of fowl. J. Genet. 54: 219–235.Google Scholar
  68. Landauer, W. 1956b. Hereditary and induced cross-beak of fowl. Experiments with ethyl carbamate. J. Exp. Zool. 132: 25–38.Google Scholar
  69. Landauer, W. 1956c. The teratogenic activity of pilocarpine, pilocarpidine and their isomers, with special reference to the importance of steric configuration. J. Exp. Zool. 132: 39–50.Google Scholar
  70. Landauer, W. 1957a. Phenocopies and genotype, with special reference to sporadically-occurring developmental variants. Amer. Nat. 91: 79–90.Google Scholar
  71. Landauer, W. 1957b. Niacin antagonists and chick development. J. Exp. Zool. 136: 509–530.PubMedGoogle Scholar
  72. Landauer, W. 1958. On phenocopies, their developmental physiology and genetic meaning. Amer. Nat. 92: 201–213.Google Scholar
  73. Landauer, W. 1959. The phenocopy concept: illusion or reality? Experientia 15: 409–412.PubMedGoogle Scholar
  74. Landauer, W. 1960a. Nicotine-induced malformations of chicken embryos and their bearing on the phenocopy problem. J. Exp. Zool. 143: 107–122.PubMedGoogle Scholar
  75. Landauer, W. 1960b. Experiments concerning the teratogenic nature of thallium: polyhydroxy compounds, histidine and imidazole as supplements. J. Exp. ZooL 143: 101–105.PubMedGoogle Scholar
  76. Landauer, W. 1965a. Nanomelia, a lethal mutation of the fowl. J. Hered. 56: 131–138.PubMedGoogle Scholar
  77. Landauer, W. 1965b. Observations on penetrance and expressivity of Lamoreux’s chondrodystrophy of fowl. J. Hered. 56: 209–214.PubMedGoogle Scholar
  78. Landauer, W. 1965c. Gene and phenocopy: selection experiments and tests with 6-aminonicotinamide. J. Exp. Zool. 160: 345–354.PubMedGoogle Scholar
  79. Landauer, W. 1967. The Hatchability of Chicken Eggs as Influenced by Environment and Heredity. Monograph 1 (Revised) Storrs Agricultural Experiment Station. 315 pp.Google Scholar
  80. Landauer, W. 1969a. Chapter, in The Fertility and Hatchability of The Hen’s Egg. T. C. Carter and R. M. Freeman, eds. Oliver and Boyd. LondoGoogle Scholar
  81. Landauer, W. 1969b. A bibliography of micromelia. Chapter, in Limb Development and Deformity: Problems of Evaluation and rehabilitation. Charles C. Thomas.Google Scholar
  82. Landauer, W. 1972. Is insulin a teratogen?. Teratology 5: 129–135.PubMedGoogle Scholar
  83. Landauer, W. 1975a. Cholinomimetic teratogens: studies with chicken embryos. Teratology 12: 125–145.PubMedGoogle Scholar
  84. Landauer, W. 1975b. Cholinomimetic teratogens. II. Interaction with inorganic ions. Teratology 12: 271–276.PubMedGoogle Scholar
  85. Landauer, W. 1976. Cholinomimetic teratogens III. Interaction with amino acids known as neurotransmitters. Teratology 13: 41–46.PubMedGoogle Scholar
  86. Landauer, W. 1977. Cholinomimetic teratogens V. The effect of oximes and related cholinesterase reactivators. Teratology 15: 33–42.PubMedGoogle Scholar
  87. Landauer, W., and Aberle, S. D. 1935. Studies on the endocrine glands of Frizzle fowl. Am. J. Anat. 57: 99–134.Google Scholar
  88. Landauer, W., and Bliss, C. I. 1946. Insulin-induced rumplessness of chickens. III. The relationship of dosage and of developmental stage at time of injection to response. J. Exp. Zool. 102: 1–22.PubMedGoogle Scholar
  89. Landauer, W., and Clark, E. M. 1962a. Teratogenic interaction of insulin and 2-deoxy-D-glucose in chick development. J. Exp. Zool. 151: 245–252.PubMedGoogle Scholar
  90. Landauer, W., and Clark, E. M. 1962b. The interaction in teratogenic activity of the two niacin analogs 3-acetylpyridine and 6-aminonicotinamide. J. Exp. Zool. 151: 253–258.PubMedGoogle Scholar
  91. Landauer, W., and Clark, E. M. 1963. Interaction of insulin and chlorpromazine in teratogenesis. Nature. 198: 215–21PubMedGoogle Scholar
  92. Landauer, W., and Clark, E. M. 1964a. On the role of riboflavin in the teratogenic activity of boric acid. J. Exp. Zool. 156: 307–312.PubMedGoogle Scholar
  93. Landauer, W., and Clark, E. M. 1964b. On the teratogenic interaction of sulfanilamide and 3-acetylpyridine in chick development. J. Exp. Zool. 156: 313–322.PubMedGoogle Scholar
  94. Landauer, W., and Clark, E. M. 1964c. Teratogenic risks of drug synergism. Nature. 203: 527–528.PubMedGoogle Scholar
  95. Landauer, W., and Clark, E. M. 1964d. Uncouplers of oxidative phosphorylation and teratogenic activity of insulin. Nature. 204: 285–286.PubMedGoogle Scholar
  96. Landauer, W., and David, L. T. 1933. Elevated metabolism, blood cells, and hemoglobin content of the blood in the Frizzle fowl. Folia Haematol. 50: 1–14.Google Scholar
  97. Landauer, W., and Dunn, L. C. 1925. Two types of rumplessness in domestic fowls. J. Hered. 16: 153–160.Google Scholar
  98. Landauer, W., and Dunn, L. C. 1926. Chondrodystrophia in chicken embryos. Proc. Soc. Exp. Biol. Med. 23: 562–566.Google Scholar
  99. Landauer, W., and Dunn, L. C. 1930a. Studies on the Creeper fowl. I. Genetics. J. Genet. 23: 397–412.Google Scholar
  100. Landauer, W., and Dunn, L. C. 1930b. The “Frizzle” character of fowls; its expression and inheritance. J. Hered. 21: 291–305.Google Scholar
  101. Landauer, W., and Rhodes, M. B. 1952. Further observations on the teratogenic nature of insulin and its modification by supplementary treatment. J. Exp. Zool. 119: 221–261.Google Scholar
  102. Landauer, W., and Salam, N. 1972. Aspects of dimethyl sulfoxide as solvent for teratogens. Devel. Biol. 28: 35–46.Google Scholar
  103. Landauer, W., and Salam, N. 1973. Quantitative and qualitative distinctions in developmental interference produced by various substituted pyridines, molecular shape and teratogenicity as studied in chicken embryos. Acta Embryol. exp. 179–197.Google Scholar
  104. Landauer, W., and Salam, N. 1974. The experimental production in chicken embryos of muscular hypoplasia and associated defects of beak and cervical vertebrae. Acta Embryol exp. 1: 51–66.Google Scholar
  105. Landauer, W., and Sopher, D. 1970. Succinate, glycerophosphate and ascorbate as sources of cellular energy and as antiteratogens. J. Embryol. exp. Morph. 24: 187–202.PubMedGoogle Scholar
  106. Landauer, W., and Upham, E. 1936. Weight and size of organs in Frizzle fowl. Storrs Agricultural Experiment Station Bulletin 210: 1–42.Google Scholar
  107. Landauer, W., and Wakasugi, N. 1967. Problems of acetazolamide and N-ethylnicotinamide as teratogens. J. Exp. Zool 164: 499–515.PubMedGoogle Scholar
  108. Landauer, W., and Wakasugi, N. 1968. Teratological studies with sulphonamides and their implications. J. Embryol. exp. Morph. 20: 261–284.PubMedGoogle Scholar
  109. Lowenthal, L. 1957. Histological and histochemical studies on the homozygous Creeper embryo. Anat. Rec. 128: 201–212.Google Scholar
  110. Mayr, E. 1963. Animal Species and Evolution. Harvard Univ. Press. Cambridge, Mass, (cited by Landauer, 1965a).Google Scholar
  111. Meiniel, R. 1974a. Action protectrice de la pralidoxime vis-a-vis des effets tératogènes du parathion sur le squelette axial de l’embryon de caille. C. R Acad. Sci., D 279: 603–606 (cited by Landauer, 1977).Google Scholar
  112. Meiniel, R. 1974b. Etude de l’action protectrice de la pralidoxime vis-avis des anomalies squelettiques provoquees par le parathione chez l’embryon de caille japonaise. C. R. Soc. Biol. 68: 1315–1318 (cited by Landauer, 1977).Google Scholar
  113. Meiniel, R. 1975. Prevention par la pralidoxime de certains effets tératogènes induits par le bidrin chez l’embryon de caille. C. R. Acad. Sci., D 280: 1019–1022 (cited by Landauer, 1977).Google Scholar
  114. Mitchell, H. and Lipps, L. S. 1978. Heat shock and phenocopy induction in Drosophila. Cell 15: 907–918.PubMedGoogle Scholar
  115. Plunkett, R. C. 1933. A contribution to the theory of dominance. Amer. Nat. 67: 84–85.Google Scholar
  116. Roger, J.-C., Upshall, D. G. and Casida, J. E. 1969. Structure-activity and metabolism studies on organophosphate teratogens and their alleviating agents in developing hen eggs with special emphasis on Bidrin. Biochem. Pharmacol. 18: 373–392 (cited by Landauer, 1977).PubMedGoogle Scholar
  117. Rudnick, D. 1945. Differentiation of prospective limb material from Creeper chick embryos in coelomic grafts. J. Exp. Zool. 100: 1–17.Google Scholar
  118. Spofford, J. B. 1956. The relation between expressivity and selection against eyeless in Drosophila melanogaster. Genetics 41: 938–959 (cited by Landauer 1965a).PubMedGoogle Scholar
  119. Stirpe, N. S., Argraves, W. S., and Goetinck, P. F. 1987. Chondrocytes from the cartilage proteoglycan deficient mutant, nanomelia, synthesize greatly reduced levels of the proteoglycan core protein transcript. Dev. Biol. 124: 77–81.PubMedGoogle Scholar
  120. Upham, E., and Landauer, W. 1935. The relation of thickness of cutis and subcutis to hair slope in human skin. Anal Rec. 61: 359–366.Google Scholar
  121. Upshall, D. G., Roger, J.-C., and Casida, J. E. 1968. Biochemical studies on the teratogenic action of Bidrin and other neuroactive agents in developing hen eggs. Biochem. Pharmacol. 17: 1529–1542 (cited by Landauer, 1977).PubMedGoogle Scholar
  122. Veldstra, H. 1956. Synergism and potentiation with special reference to the combination of structural analogues. Physiol. Rev. 8: 339–387 (cited by Landauer, 1974)Google Scholar
  123. Veldstra, H. 1963. Synergism of drugs. Chapter, pp. 42–51, in Proc. Third Internat. Congress Chemotherap. Stuttgart 1962,(cited by Landauer and Salam, 1974).Google Scholar
  124. Wallace, H., Clyman, R. I., and Pierro, L. J. 1969. Nucleic acid deficiency in the prothanic homozygous mutant of Creeper fowl. J. Exp. Zool. 172: 245–252.PubMedGoogle Scholar
  125. Wechsler, J. A. 1935. Revolt on Campus. Covici-Friede, New York.Google Scholar
  126. Wolff, Et. and Kieny, M. 1963. Recherches sur la nature d’un facteur inhibiteur de la croissance des os longs dans la race de poule Creeper. Develop. Biol. 7: 324–341.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Hugh Clark
    • 1
  • Louis J. Pierro
    • 2
  1. 1.StorrsUSA
  2. 2.Storrs Agricultural Experiment StationUniversity of ConnecticutStorrsUSA

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