Surfactant Replacement Therapy in Animal Models of Respiratory Failure Due to Viral Infection

  • A. van’t Veen
  • K. L. So
  • B. Lachmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 345)


Several studies have shown that during the development of respiratory failure in the adult respiratory distress syndrome (ARDS), the pulmonary surfactant system is disturbed1–5. One of the current promising therapeutic approaches in ARDS is, therefore, re-establishment of the functional integrity of the damaged surfactant system by intratracheal instillation of surfactant. The first clinical trials6,7 and results from experimental studies on ARDS have shown that exogenous surfactant application can restore lung function in ARDS (for review see references 8 and 9). Due to the great variance in etiology of ARDS it is, however, a necessity to investigate surfactant replacement therapy in different models of respiratory failure. Therefore, we studied the effect of surfactant substitution in two animal models of severe respiratory failure due to viral pneumonia.


Adult Respiratory Distress Syndrome Surfactant System Lung Mechanic Sendai Virus Viral Pneumonia 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • A. van’t Veen
    • 1
  • K. L. So
    • 1
  • B. Lachmann
    • 1
  1. 1.Dept. of AnaesthesiologyErasmus University RotterdamThe Netherlands

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