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Iron-Sulphur Nitrosyl Complexes: High Capacity, Photosensitive No-Generators that Target Vascular Endothelium

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 257))

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Abstract

Iron-sulphur cluster nitrosyls (A: tetranitrosyltetra-u3-sulphidotetrahedrotetrainron and B: heptanitrosyl-u3-thioxotetraferrate (1-)_ spontaneously decompose in solution to generate nitric oxide (NO •). Segments of rat isolated tail artery (7-10 mm) were perfused internally (2ml • min-1) with Krebs’ solution containing phenylephrine (4-10µM). Experiments were performed in the dark.

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Authors and Affiliations

  1. Cancer Research Group School of Biological and Medical Sciences, University of St. Andrews, St. Andrews, Fife, Scotland, KY16 9TS

    F. W. Flitney, I. L. Megson, J. L. M. Thomson, G. Kennovin & A. R. Butler

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  1. F. W. Flitney
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  2. I. L. Megson
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  3. J. L. M. Thomson
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  4. G. Kennovin
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  5. A. R. Butler
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Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    John D. Catravas

  2. Washington University Medical School, St. Louis, Missouri, USA

    Allan D. Callow

  3. T Cell Sciences, Inc., Cambridge, Massachusetts, USA

    Una S. Ryan

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© 1993 Springer Science+Business Media New York

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Flitney, F.W., Megson, I.L., Thomson, J.L.M., Kennovin, G., Butler, A.R. (1993). Iron-Sulphur Nitrosyl Complexes: High Capacity, Photosensitive No-Generators that Target Vascular Endothelium. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2437-3_27

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  • DOI: https://doi.org/10.1007/978-1-4615-2437-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6035-3

  • Online ISBN: 978-1-4615-2437-3

  • eBook Packages: Springer Book Archive

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