Sialodacryoadenitis Virus Infection of Rat Lacrimal Gland Acinar Cells

  • L. Alexandra Wickham
  • Zhiyan Huang
  • Ross W. Lambert
  • David A. Sullivan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 350)


The secretory immune system of the eye is designed to protect the ocular surface against microbial challenge and infectious disease.1 This immunological role is mediated primarily through secretory IgA (sIgA) antibodies, which are produced by plasma cells in interstitial areas of the lacrimal gland and are selectively transported to tears by secretory component (SC), the polymeric TgA receptor.1 After delivery to the eye’s anterior surface, sIgA antibodies may act to prevent viral internalization, inhibit bacterial colonization, curtail parasitic infestation and attenuate toxin-related damage.2


Methylene Blue Acinar Cell Ocular Surface Lacrimal Gland Secretory Component 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • L. Alexandra Wickham
    • 1
  • Zhiyan Huang
    • 1
  • Ross W. Lambert
    • 1
  • David A. Sullivan
    • 1
  1. 1.Department of Ophthalmology, Harvard Medical School and Immunology UnitSchepens Eye Research InstituteBostonUSA

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