Lyme Borreliosis pp 155-167 | Cite as
Expression of Public Idiotypes in Patients with Lyme Arthritis
Chapter
Abstract
Joints are often affected in Lyme disease and in some instances this may be due to immune auto-reactivity. To characterise further the immune response in this disease investigations were carried out to determine the expression of three public idiotypes on serum immunoglobulins in patients with Lyme disease during the development of varying degrees of arthritis.
Keywords
Healthy Control Subject Lyme Disease Serum Immunoglobulin Active Systemic Lupus Erythematosus Erythema Migrans
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- (1).Steere AC. Lyme disease. N Engl J Med (1989); 321: 586–596.PubMedCrossRefGoogle Scholar
- (2).Grodzicki RL, Steere AC. Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparation for diagnosing early Lyme disease. J Infect Dis (1988); 157: 790–799.PubMedCrossRefGoogle Scholar
- (3).Mackworth-Young CG, Harris EN, Steere AC et al. Anti-cardiolipin antibodies in Lyme disease. Arthritis Rheum (1988); 31: 1052–1056.PubMedCrossRefGoogle Scholar
- (4).Shoenfeld Y, Isenberg DA, Rauch J, Madaio MP, Stollar BD, Schwartz RS. Idiotypic cross-reactions of monoclonal human lupus autoantibodies. J Exp Med (1983); 158: 718–730.PubMedCrossRefGoogle Scholar
- (5).Williams W, Zumla A, Behrens R et al. Studies of a common idiotype PR4 in autoimmune rheumatic disease. Arthritis Rheum (1988); 31: 1097–1104PubMedCrossRefGoogle Scholar
- (6).Watts TA, Ravirajan CT, Staines NA, Isenberg DA. A human fetal monoclonal DNA-binding antibody shares idiotypes with fetal and adult murine monoclonal DNA-binding antibodies. Immunology (1990); 69: 348–354.PubMedGoogle Scholar
- (7).Chen PP, Liu MR, Sinha S, Carson DA. A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum (1988); 31: 1429–1431.PubMedCrossRefGoogle Scholar
- (8).Isenberg DA, Collins C. Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue bound immunoglobulins from lupus patients. J Clin Invest (1985); 67: 287–294.CrossRefGoogle Scholar
- (9).Beradi VP, Weeks KE, Steere AC. Serodiagnosis of early Lyme disease: analysis of IgM and IgG antibody responses by using an antibody-capture enzyme immunoassay. J Infect Dis (1988); 158: 754–760.CrossRefGoogle Scholar
- (10).Long AA, Ginsberg JS, Brill-Edwards P et al. The relationship of antiphospholipid antibodies to thromboembolic disease in system lupus erythematosus: a cross sectional study. Thromb Haemost (1991); 66: 520–524.PubMedGoogle Scholar
Copyright information
© Springer Science+Business Media New York 1994