RNA Helicase Activity in Translation Initiation in Eukaryotes

  • Arnim Pause
  • Nahum Sonenberg


Eukaryotic translation initiation is significantly different than in prokaryotes in several respects. 1) A cap structure (m7GpppX, where X is any nucleotide) that is present at the 5’ end of most eukaryotic mRNAs enhances translational efficiency. 2) mRNA binding to ribosome is dependent on ATP hydrolysis in eukaryotes, but not in prokaryotes. 3) A Shine-Dalgarno sequence plays a critical role in the selection of the initiator codon in prokaryotes, but not in eukaryotes. These differences in the mechanisms of translation are reflected in the considerable larger number of initiation factors in eukaryotes as compared to prokaryotes.


Helicase Activity Short RNAs mRNA Secondary Structure mRNA Binding Dead Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Arnim Pause
    • 1
  • Nahum Sonenberg
    • 1
  1. 1.Department of Biochemistry and McGill Cancer CenterMcGill UniversityMontrealCanada

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