Recombinant Hematopoietic Growth Factors in Bone Marrow Transplantation

  • John Nemunaitis
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 76)

Abstract

Hematopoietic growth factors are naturally occurring glycoproteins that stimulate the proliferation of hematopoietic cells [1–3]. Initial discovery of hematopoietic growth factors was based on proliferative activity identified by in vitro assay systems. Erythropoietin (EPO) stimulates erythrocyte maturation, granulocyte-colony-stimulating factor (G-CSF) stimulates neutrophil proliferation, and granulocyte-macrophage-colony-stimulating factor (GM-CSF) stimulates neutrophil, monocyte, and macrophage proliferation. These three recombinant cytokines have been approved by the Food and Drug Administration (FDA) for clinical use and have been and are being evaluated in patients undergoing bone marrow or peripheral blood stem cell transplantation.

Keywords

Bone Marrow Transplantation Stem Cell Factor Allogeneic Bone Marrow Allogeneic Bone Marrow Transplantation Autologous Hematopoietic Stem Cell Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 1995

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  • John Nemunaitis

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