Analysis of SP/VIP Fiber Association with T4 and T8 Lymphocytes in Normal Human Colon

  • P. Weisz-Carrington
  • N. Nagamoto
  • M. Farraj
  • R. Buschmann
  • E. B. Rypins
  • A. Stanisz
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

The possibility that neuropeptides control many facets of the secretory immune system is now an established fact.1 In addition, a variety of receptors for neuropeptides have been described on lymphocytes.2 A close contact between specialized nerve fibers and lymphocytes has been demonstrated in the rat spleen.3 This neighboring contact suggests that for neuropeptides to act on immunocytes, this close range between fibers and cells is required. Others have also observed a proximity between Substance P and IgA producing lymphocytes.4 In other work, we have demonstrated that IgA cells have a highly significant relationship by proximity, to SP fibers rather than VIP fibers in the colonic mucosa.5 Since such proximity does not appear to occur randomly, we posed the question that SP-fibers might also be associated with lymphoid cells, such as T cells known to influence differentiation and maturation of B cells in the lamina propria of mucosal surfaces.

Keywords

Lamina Propria Alkaline Phosphatase Substrate Paraffin Embed Section Neighboring Contact Normal Human Colon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • P. Weisz-Carrington
    • 1
    • 2
    • 3
  • N. Nagamoto
    • 1
    • 2
    • 3
  • M. Farraj
    • 1
    • 2
    • 3
  • R. Buschmann
    • 1
    • 2
    • 3
  • E. B. Rypins
    • 1
    • 2
    • 3
  • A. Stanisz
    • 1
    • 2
    • 3
  1. 1.Departments of Pathology and SurgeryWest Side VAMCUSA
  2. 2.University of Illinois at ChicagoUSA
  3. 3.McMaster UniversityCanada

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