Induction of a Protective Immune Response to Murine Coronavirus with Non-Internal Image Anti-Idiotypic Antibodies

  • Mathilde Yu
  • Pierre J. Talbot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 380)


Neurotropic murine coronaviruses (MHV) provide an excellent animal model to study experimental modulation of the immune response to a viral pathogen with anti-idio-typic antibodies. It is known that among the various types of anti-idiotypic antibodies (anti-Id), those designated beta (β) or internal image can molecularly mimic the antigen and induce biological activities such as anti-viral protection and neutralization. We have recently shown that polyclonal non-internal image anti-idiotypic antibodies of the β-type could induce protective anti-coronavirus immunity1.

In the present study, a polyclonal anti-Id (Ab2) was induced against a neutralizing murine monoclonal antibody (MAbl), designated 5B170.11. Mice immunized with this affinity-purified rabbit Ab2α, a non-internal image antibody, were partially protected against lethal infection by the JHM strain of MHV. However, other polyclonal and monoclonal non-internal image Ab2 induced against another neutralizing MAbl, designated 4-11G.6, were not able to protect mice against lethal infection with the A59 strain of MHV.

These results demonstrate that anti-viral protection by altering the idiotypic network with non-internal image-bearing anti-idiotype reagents can be achieved even with some anti-Id of the α-type.


Protective Immune Response Internal Image Lethal Infection Neutralization Titer ELISA Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Mathilde Yu
    • 1
  • Pierre J. Talbot
    • 1
  1. 1.Laboratory of Neuroimmunovirology, Virology Research Center, Institut Armand-FrappierUniversité Du QuébecLavalCanada

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