Fragmentation and Rearrangement of the Golgi Apparatus During MHV Infection of L-2 Cells
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The Golgi apparatus-complex (GA) plays a seminal role in the transport, processing and targeting of polypeptides synthesized in the rough endoplasmic reticulum (RER). Important insight into the function of the GA has been gained with the use of viruses or their coat glycoproteins which are processed through the GA. Coronavirus mouse hepatitis virus (MHV), possesses a membrane protein (M) which is targeted to the trans-Golgi network (TGN) 1.
KeywordsAmyotrophic Lateral Sclerosis Rough Endoplasmic Reticulum Syncytium Formation Mouse Hepatitis Virus Herpes Simplex ViruS
- 7.Campadelli G, Brandimarti R, Di Lazzaro C, Ward PL, Roizman B, Torrisi MR. Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 1993;90:2798–2802.PubMedCrossRefGoogle Scholar