The PITSLRE protein kinase family

  • Jill M. Lahti
  • Jialing Xiang
  • Vincent J. Kidd
Chapter
Part of the Progress in Cell Cycle Research book series (PCCR)

Abstract

A family of p34cdc2 related protein kinases, the PITSLRE kinases, is generated by alternative splicing and promoter utilization from three duplicated and tandemly linked genes on human chromosome 1p36.3, which is frequently deleted during the late stages of tumorigenesis. PITSLRE mRNA, protein, and enzyme activity are induced during Fas receptor- and glucocorticoid-mediated apoptosis of human T cells. Several PITSLRE isoforms are specific targets of proteolysis during apoptosis, generating an enzymatically active 50 kDa isoform. Inhibition of this protease activity blocks PITSLRE processing and enzyme activation, as well as apoptosis. Thus, PITSLRE kinases may be integral downstream components of apoptotic signal transduction pathway(s). Furthermore, PITSLRE genes, and their products, are physically altered in human neuroblastoma tumors, suggesting that they may be tumor suppressors.

Keywords

Apoptotic Signal Transduction Cell Cycle Transit Apoptotic Signal Transduction Pathway Promoter Utilization Human Fetal Liver cDNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Hartwell, L. H., Culotti, J., Pringle, J. R. & Reid, B. J. (1974) Science 183, 46–51.PubMedCrossRefGoogle Scholar
  2. 2.
    Nurse, P. (1990) Nature 344, 503–508.PubMedCrossRefGoogle Scholar
  3. 3.
    Norbury, C. & Nurse, P. (1990) Ciba. Found. Symp. 150, 168–177.PubMedGoogle Scholar
  4. 4.
    Maller, J. L. (1991) Curr. Opin. Cell Biol. 3, 269–275.PubMedCrossRefGoogle Scholar
  5. 5.
    Lewin, B. (1990) Cell 61, 743–752.PubMedCrossRefGoogle Scholar
  6. 6.
    Weinert, T. A. & Hartwell, L. H. (1988) Science 241, 317–322.PubMedCrossRefGoogle Scholar
  7. 7.
    Hartwell, L. H. & Weinert, T. A. (1989) Science 246, 629–634.PubMedCrossRefGoogle Scholar
  8. 8.
    Rowley, R., Hudson, J. & Young, P. G. (1992) Nature 356, 353–355.PubMedCrossRefGoogle Scholar
  9. 9.
    Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. & Kastan, M. B. (1992) Proc. Natl. Acad. Sci., USA 89, 7491–7495.PubMedCrossRefGoogle Scholar
  10. 10.
    Lowe, S. W., Ruley, H. E., Jacks, T. & Housman, D. E. (1993) Cell 74, 957–967.PubMedCrossRefGoogle Scholar
  11. 11.
    Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. (1993) Nature 362, 847–849.PubMedCrossRefGoogle Scholar
  12. 12.
    Lowe, S. W. & Ruley, H. E. (1993) Genes & Devel. 7, 535–545.CrossRefGoogle Scholar
  13. 13.
    Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T. & Van Dyke, T. (1994) Cell 78, 703–711.PubMedCrossRefGoogle Scholar
  14. 14.
    Wylie, A. H., Kerr, J. F. R. & Currie, A. R. (1981) Int. Rev. Cytol. 68, 251–305.CrossRefGoogle Scholar
  15. 15.
    Cohen, J. J. (1991) Adv. Immunol. 50, 55–85.PubMedCrossRefGoogle Scholar
  16. 16.
    Raff, M. C. (1992) Nature 356, 397–400.PubMedCrossRefGoogle Scholar
  17. 17.
    Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S., Ishizaki, Y. & Jacobson, M. D. (1993) Science 262, 695–700.PubMedCrossRefGoogle Scholar
  18. 18.
    Yu, H., Bauer, B., Lipke, G. K., Phillips, R. L. & Van Zant, G. (1993) Blood 81, 373–384.PubMedGoogle Scholar
  19. 19.
    Wylie, A. H. (1980) Nature 284, 555–556.CrossRefGoogle Scholar
  20. 20.
    Peitsch, M. C., Polzar, B., Stephan, H., Crompton, T., MacDonald, H. R., Mannherz, H. G. & Tschopp, J. (1993) EMBO J. 12, 371–377.PubMedGoogle Scholar
  21. 21.
    Martin, S. J., Bonham, A. M. & Cotter, T. G. (1990) Biochem. Soc. Trans. 18, 634–636.PubMedGoogle Scholar
  22. 22.
    Martin, S. J., Lennon, S. V., Bonham, A. M. & Cotter, T. G. (1990) J. Immunol. 145, 1859–1867.PubMedGoogle Scholar
  23. 23.
    Dive, C. & Hickman, J. A. (1991) Br. J. Cancer 64, 192–196.PubMedCrossRefGoogle Scholar
  24. 24.
    Hickman, J. A. (1992) Cancer Metastasis Rev. 11, 121–139.PubMedCrossRefGoogle Scholar
  25. 25.
    Lowe, S. W., Jacks, T., Housman, D. E. & Ruley, H. E. (1994) Proc. Natl. Acad. Sci., USA 91, 2026–2030.PubMedCrossRefGoogle Scholar
  26. 26.
    Fisher, D. E. (1994) Cell 78, 539–542.PubMedCrossRefGoogle Scholar
  27. 27.
    Williams, G. T. & Smith, C. A. (1993) Cell 74, 777–779.PubMedCrossRefGoogle Scholar
  28. 28.
    Schwartz, L. M. & Osborne, B. A. (1993) Immunol. Today 14, 582–590.PubMedCrossRefGoogle Scholar
  29. 29.
    Ellis, H. M. & Horvitz, H. R. (1986) Cell 44, 817–829.PubMedCrossRefGoogle Scholar
  30. 30.
    Ellis, R. E., Yuan, J. & Horvitz, H. R. (1991) in Annual Review of Cell Biology, Annual Reviews Inc., pp. 663–698.Google Scholar
  31. 31.
    Sulston, J. E. & Horvitz, H. R. (1977) Dev. Biol. 82, 110–156.CrossRefGoogle Scholar
  32. 32.
    Yuan, J. & Horvitz, H. R. (1992) Development 116, 309–320.PubMedGoogle Scholar
  33. 33.
    Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. (1993) Cell 75, 641–652.PubMedCrossRefGoogle Scholar
  34. 34.
    Hengartner, M. O., Ellis, R. E. & Horvitz, H. R. (1992) Nature 356, 494–499.PubMedCrossRefGoogle Scholar
  35. 35.
    Hengartner, M. O. & Horvitz, H. R. (1994) Cell 76, 665–676.PubMedCrossRefGoogle Scholar
  36. 36.
    Oltvai, Z. N., Milliman, C. L. & Korsmeyer, S. J. (1993) Cell 74, 609–619.PubMedCrossRefGoogle Scholar
  37. 37.
    Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G. & Thompson, C. B. (1993) Cell 74, 597–608.PubMedCrossRefGoogle Scholar
  38. 38.
    Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L. (1991) Oncogene 6, 1915–1922.PubMedGoogle Scholar
  39. 39.
    Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M, Penn, L. Z. & Hancock, D. C. (1992) Cell 69, 119–128.PubMedCrossRefGoogle Scholar
  40. 40.
    Harrington, E. A., Bennett, M. R., Fanidi, A. & Evan, G. I. (1994) EMBO J. 13, 3286–3295.PubMedGoogle Scholar
  41. 41.
    Sellins, K. S. & Cohen, J. J. (1987) J. Immunol 139, 3199–3206.PubMedGoogle Scholar
  42. 42.
    Kizaki, H., Tadakuma, T., Odaka, C., Muramatsu, J. & Ishimura, Y. (1989) J. Immunol 143, 1790–1794.PubMedGoogle Scholar
  43. 43.
    McConkey, D. J., Hartzell, P., Duddy, S. K., Hakansson, H. & Orrenius, S. (1988) Science 242, 256–259.PubMedCrossRefGoogle Scholar
  44. 44.
    Cohen, J. J. (1992) Semin. Immunol 4, 363–369.PubMedGoogle Scholar
  45. 45.
    Doherty, P. C. (1993) Cell 75, 607–612.PubMedCrossRefGoogle Scholar
  46. 46.
    Sarin, A., Adams, D. H. & Henkart, P. A. (1993) J. Exp. Med. 178, 1693–1700.PubMedCrossRefGoogle Scholar
  47. 47.
    Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A. & Yuan, J. (1993) Cell 75, 653–660.PubMedCrossRefGoogle Scholar
  48. 48.
    Wilson, K. P, Black, J. F., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A. & Livingston, D. J. (1994) Nature 370, 270–275.PubMedCrossRefGoogle Scholar
  49. 49.
    Oberhammer, F. A., Hochegger, K., Froschl, G., Tiefenbacher, R. & Pavelka, M. (1994) J. Cell Biol. 126, 827–837.PubMedCrossRefGoogle Scholar
  50. 50.
    Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G. & Earnshaw, W. C. (1993) J. Cell Biol. 123, 7–22.PubMedCrossRefGoogle Scholar
  51. 51.
    Shi, L., Nishioka, W. K., Th’ng, J., Bradbury, E. M., Litchfield, D. W. & Greenberg, A. H. (1994) Science 263, 1143–1145.PubMedCrossRefGoogle Scholar
  52. 52.
    Liu, Z. G., Smith, S. W., McLaughlin, K. A., Schwartz, L. M. & Osborne, B. A. (1994) Nature 367, 281–284.PubMedCrossRefGoogle Scholar
  53. 53.
    Woronicz, J. D., Calnan, B., Ngo, V. & Winoto, A. (1994) Nature 367, 277–281.PubMedCrossRefGoogle Scholar
  54. 54.
    Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R. W. (1991) Cancer Res. 51, 6304–6311.PubMedGoogle Scholar
  55. 55.
    Dulic, V., Kaufmann, W. K., Wilson, S. J., Tlsty, T. D., Lees, E., Harper, J. W., Elledge, S. J. & Reed, S. I. (1994) Cell 76, 1013–1023.PubMedCrossRefGoogle Scholar
  56. 56.
    Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B. & Costa, J. (1992) Proc. Natl. Acad. Sci., USA 89, 4495–4499.PubMedCrossRefGoogle Scholar
  57. 57.
    Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A. & Oren, M. (1991) Nature 352, 345–347.PubMedCrossRefGoogle Scholar
  58. 58.
    White, E. & Cipriani, R. (1990) Mol. Cell. Biol. 10, 120–130.PubMedGoogle Scholar
  59. 59.
    Debbas, N. & White, E. (1993) Genes & Devel. 7, 546–554.CrossRefGoogle Scholar
  60. 60.
    Rao, L., Debbas, M., Sabbatini, P., Hockenbery, D., Korsmeyer, S. & White, E. (1992) Proc. Natl. Acad. Sci., USA 89, 7742–7746.PubMedCrossRefGoogle Scholar
  61. 61.
    Chiou, S. K., Rao, L. & White, E. (1994) Mol. Cell. Biol. 14, 2556–2563.PubMedCrossRefGoogle Scholar
  62. 62.
    Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M. & Nevins, J. R. (1991) Cell 65, 1053–1061.PubMedCrossRefGoogle Scholar
  63. 63.
    Lees, E., Faha, B., Dulic, V., Reed, S. I. & Harlow, E. (1992) Genes & Devel. 6, 1874–1885.CrossRefGoogle Scholar
  64. 64.
    Nevins, J. R. (1992) Science 258, 424–429.PubMedCrossRefGoogle Scholar
  65. 65.
    Wu, X. & Levine, A. J. (1994) Proc. Natl. Acad. Sci.,USA 91, 3602–3606.PubMedCrossRefGoogle Scholar
  66. 66.
    Meyerson, M., Enders, G. H., Wu, C-L., Su, L-K., Gorka, C., Nelson, C., Harlow, E. & Tsai, L-H. (1992) EMBO J. 11, 2909–2917.PubMedGoogle Scholar
  67. 67.
    Xiang, J., Lahti, J. M., Grenet, J., Easton, J. & Kidd, V. J. (1994) J. Biol. Chem. 269, 15786–15794.PubMedGoogle Scholar
  68. 68.
    Eipers, P. G., Barnoski, B. L., Han, J., Carroll, A. J. & Kidd, V. J. (1991) Genomics 11, 621–629.PubMedCrossRefGoogle Scholar
  69. 69.
    Bunnell, B. A., Heath, L. S., Adams, D. E., Lahti, J. M. & Kidd, V. J. (1990) Proc. Natl. Acad. Sci., USA 87, 7467–7471.PubMedCrossRefGoogle Scholar
  70. 70.
    Lahti, J. M., Xiang, J., Heath, L. S., Campana, D. & Kidd, V. J. (1995) Mol. Cell. Biol. 15, 1–11.PubMedGoogle Scholar
  71. 71.
    Xiang, J., Lahti, J. M. & Kidd, V. J. (1994) Biochem. Biophys. Res. Comm. 199, 1167–1173.PubMedCrossRefGoogle Scholar
  72. 72.
    Andreassen, P. R. & Margolis, R. L. (1992) Proc. Natl. Acad. Sci., USA 89, 2272–2276.PubMedCrossRefGoogle Scholar
  73. 73.
    Mock, B. A., Padlan, C., Kozak, C. A. & Kidd, V. (1994) Mammalian Genome 5, 191–192.PubMedCrossRefGoogle Scholar
  74. 74.
    Lahti, J. M., Valentine, M., Xiang, J., Joens, B., Amann, J., Grenet, J., Richmond, G., Look, A. T. & Kidd, V. J. (1994) Nature Genetics 7, 370–375.PubMedCrossRefGoogle Scholar
  75. 75.
    Li, H., Grenet, J., Valentine, M., Lahti, J. M. & Kidd, V. J. (1995) Gene 153, 237–242.PubMedCrossRefGoogle Scholar
  76. 76.
    Malek, S. N. & Desiderio, S. (1994) J. Biol. Chem. 269, 33009–33020.PubMedGoogle Scholar
  77. 77.
    Jacobson, M. D., Burne, J. F. & Raff, M. C. (1994) EMBO J. 13, 1899–1910.PubMedGoogle Scholar
  78. 78.
    Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. & Earnshaw, W. C. (1994) Nature 371, 347–348.CrossRefGoogle Scholar
  79. 79.
    Soderling, T. R. (1990) J. Biol. Chem. 265, 1823–1826.PubMedGoogle Scholar
  80. 80.
    Parker, P. J., Coussens, L., Totty, N., Rhee, L., Young, S., Chen, E., Stabel, S., Waterfield, M. D. & Ullrich, A. (1986) Science 233, 853–859.PubMedCrossRefGoogle Scholar
  81. 81.
    Tallant, E. A., Brumley, L. M. & Wallace, R. W. (1988) Biochemistry 27, 2205–2211.PubMedCrossRefGoogle Scholar
  82. 82.
    Hashimoto, Y., Perrino, B. A. & Soderling, T. R. (1990) J. Biol. Chem. 265, 1924–1927.PubMedGoogle Scholar
  83. 83.
    Kemp, B. E. & Pearson, R. B. (1990) Trends Biochem Sci. 15, 342–346.PubMedCrossRefGoogle Scholar
  84. 84.
    Shi, L., Kam, C. M., Powers, J. C., Aebersold, R. & Greenberg, A. H. (1992) J Exp. Med. 176, 1521–1529.PubMedCrossRefGoogle Scholar
  85. 85.
    Brodeur, G. M., Green, A. A., Hayes, F. A., Williams, K. J., Williams, D. L. & Tsiatis, A. A. (1981) Cancer Res. 41, 4678–4686.PubMedGoogle Scholar
  86. 86.
    Fong, C., Dracopoli, N. C., White, P. S., Merril, P. T., Griffith, R. C., Housman, D. E. & Brodeur, G. M. (1989) Proc. Natl. Acad. Sci., USA 86, 3753–3757.PubMedCrossRefGoogle Scholar
  87. 87.
    Fong, C., White, P. S., Peterson, K., Sapienza, C., Cavenee, W. K., Kern, S. E., Vogelstein, B., Cantor, A. B., Look, A. T. & Brodeur, G. M. (1992) Cancer Res. 52, 1780–1785.PubMedGoogle Scholar
  88. 88.
    Caron, H., van Sluis, P., van Hoeve, M., de Kraker, J., Bras, J., Slater, R., Mannens, M., Voute, P. A., Westerveld, A. & Versteeg, R. (1993) Nature Genetics 4, 187–190.PubMedCrossRefGoogle Scholar
  89. 89.
    Look, A. T., Hayes, A., Shuster, J. J., Douglass, E. C., Castleberry, R. P., Bowman, L. C., Smith, E. I. & Brodeur, G. M. (1991) J. Clin. Onc. 9, 581–591.Google Scholar
  90. 90.
    Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E. & Bishop, J. M. (1984) Science 224, 1121–1124.PubMedCrossRefGoogle Scholar
  91. 91.
    Schleiermacher, G., Peter, M., Michon, J., Hugot, J-P., Vielh, P., Zucker, J-M., Magdelenat, H., Thomas, G. & Delattre, O. (1994) Genes Chrom. & Cancer 10, 275–281.CrossRefGoogle Scholar
  92. 92.
    Takeda, O., Homma, C., Maseki, N., Sakurai, M., Kanda, N., Scwab, M., Nakamura, Y. & Kaneko, Y. (1994) Genes Chrom. & Cancer 10, 30–39.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Jill M. Lahti
    • 1
  • Jialing Xiang
    • 1
    • 2
  • Vincent J. Kidd
    • 1
  1. 1.Department of Tumor Cell BiologySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of Cell BiologyUniversity of Alabama at BirminghamBirminghamUSA

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