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Function and regulation of cdc25 protein phosphatase through mitosis and meiosis

  • Catherine Jessus
  • René Ozon
Part of the Progress in Cell Cycle Research book series (PCCR)

Abstract

Activation of the cyclin B-cdc2 kinase mitotic inducer involves dephosphorylation of two inhibitory residues, tyrosine 15 and threonine 14. cdc25 is the specific phosphatase that directly dephosphorylates and activates the cdc2 kinase. cdc25 activity is regulated by phosphorylation. Both phosphatases 1 and 2A could act as cdc25-specific inhibitory phosphatases. Although the cyclin B-cdc2 complex plays a role in activating cdc25, it is highly probable that a distinct protein kinase is involved as a trigger in cdc25 activation. The implication of raf kinase as a cdc25-specific activating kinase in human cells and Xenopus oocytes is discussed.

Keywords

Xenopus Oocyte Okadaic Acid Meiotic Maturation Cdc25 Protein Nuclear Envelope Breakdown 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Catherine Jessus
    • 1
  • René Ozon
    • 1
  1. 1.Laboratoire de Physiologie de la Reproduction, INRA/URA-CNRS 1449Université Pierre et Marie CurieParis cedex 05France

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