The Role of Growth Factors in Tissue Repair IV

Type β-Transforming Growth Factor and Stimulation of Fibrosis
  • Rchard K. Assoian
Chapter

Abstract

Type β-transforming growth factor (TGF-β) is a low-molecular-weight protein with a broad array of biologic effects, including the ability both to stimulate and inhibit the proliferation of cells in culture (Tucker et al., 1984; Roberts et al., 1985; Sporn et al., 1986). This chapter focuses on a single aspect of TGF-β action: its ability to induce a striking wound-healing response in several whole-animal and cell-culture model systems. These results, considered with experiments showing storage of TGF-β in platelets and release of TGF-β during platelet degranulation, strongly suggest that this growth factor has an important physiologic role as an endogenous mediator of wound repair and fibrosis.

Keywords

Transform Growth Factor Soft Agar Human Platelet Wound Repair Epidermal Growth Factor Recep 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Rchard K. Assoian
    • 1
  1. 1.Department of Biochemistry and Molecular Biophysics, Center for Reproductive Sciences, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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