Gene Delivery in the ICU

  • Daniel J. Weiss


There are many potential applications for gene therapy in the intensive care setting. Gene transfer driven expression of substances that interfere with inflammatory mechanisms may modulate the acute inflammation accompanying many critical illnesses. Similarly, transgene expression that restores production of crucial biological mediators affected by the acute illness may be beneficial. Transgene expression need also not be limited to naturally occurring biological products. For example, cDNA can be constructed that will encode for novel synthetic anti-microbial peptides with potential for use in sepsis or other infections. However, despite these possibilities, gene therapy for critical illnesses remains an underexplored area.


Gene Therapy Acute Lung Injury Gene Delivery Cystic Fibrosis Transmembrane Conductance Regulator Adenoviral Vector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Daniel J. Weiss
    • 1
  1. 1.Fred Hutchinson Cancer Research CenterSeattleUSA

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