Gastric Proteolysis in Preterm Infants Fed Mother’s Milk or Formula

  • Theresa R. Henderson
  • Margit Hamosh
  • Martine Armand
  • Nitin R. Mehta
  • Paul Hamosh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 501)


Gastric proteolysis is assumed to be low in the newborn (Britton & Koldovsky 1989). Postprandial pepsin output is significantly lower in preterm infants than adults, 589 vs. 3352U/kg, respectively (Armand et al. 1995, 1996). We now report on gastric proteolysis in preterm infants (gestation age, 29 weeks; postnatal age, 5-6 weeks) gavage-fed mother’s milk or preemie formula. The data show that a) the nonprotein component is higher in human milk than formula, b) net proteolysis amounts to 15% of protein, c) gastric proteolysis is lower than lipolysis and, contrary to the latter, is not enhanced by milk feeding (Armand et al. 1996). We suggest that stomach pH, enzyme output, and food structure are the reasons for differences in gastric digestion of protein and fat in infants.


Human Milk Milk Protein Bovine Colostrum Gastric Aspirate Duodenal Juice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Theresa R. Henderson
    • 1
  • Margit Hamosh
    • 1
  • Martine Armand
    • 1
  • Nitin R. Mehta
    • 1
  • Paul Hamosh
    • 1
  1. 1.Departments of Pediatrics and Physiology and BiophysicsGeorgetown University Medical Center

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