The cGMP-Phosphodiesterase β-Subunit Gene

Transcriptional and Post-Transcriptional Regulation
  • Debora B. Farber
  • Leonid E. Lerner
  • Yekaterina E. Gribanova
  • Mark R. Verardo
  • Natik I. Piriev
  • Barry E. Knox
Chapter

Abstract

Mutations in the protein-coding region of the gene encoding the (β-subunit of cyclic GMP-phosphodiesterase (β-PDE) cosegregate with retinal degeneration affecting humans1, mice2,3 and dogs4,5. Moveover, given that the exonic sequences are intact, the lack or the suboptimal expression of the β-PDE gene can cause alterations in phototransduction leading to photoreceptor functional and structural abnormalities. In light of the involvement of the β-PDE gene defects in the development of retinal disease, it is important to understand the events that regulate the expression of this gene in rod photoreceptors of the human retina.

Keywords

Retinal Degeneration Relative Luciferase Activity Galactosidase Activity Retinoblastoma Cell RPE65 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Debora B. Farber
    • 1
  • Leonid E. Lerner
    • 1
  • Yekaterina E. Gribanova
    • 1
  • Mark R. Verardo
    • 1
  • Natik I. Piriev
    • 1
  • Barry E. Knox
    • 2
  1. 1.Jules Stein Eye InsituteUCLA School of MedicineLos AngelesUSA
  2. 2.Departments of Biochemistry & Molecular Biology and OphthalmologySUNY HSC at SyracuseSyracuseUSA

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