Specific Cleavage of 28S Ribosomal RNA in Murine Coronavirus-Infected Cells
- 54 Downloads
Mouse hepatitis virus (MHV), a prototypic Coronavirus, causes gastrointestinal and upper respiratory tract illnesses in animals and man. The 32 kb-long MHV genome is a positive-sense, single-stranded RNA (Lai et al 1981, Lee et al 1991) that encodes 11 open reading frames, expressed through the production of a genomic-size and six to eight species of subgenomic mRNAs (Lai et al 1981). Genomic-size mRNA encodes the 5’-most 22 kb-long gene 1, which encodes the RNA Polymerase function (Lee et al 1991). MHV contains three envelope proteins, S, M and E proteins. S protein binds to the Coronavirus receptor (Dveskler et al 1991). M and E proteins are important for the formation of the MHV envelope (Kim et al 1997).
KeywordsMouse Hepatitis Virus Respiratory Tract Illness Host Protein Synthesis Subgenomic mRNAs Viral RNase
- Dveksler, G. S., Pensiero, M. N., Cardellichio, C. B., Williams, R. K., Jiang, G.-S., Holmes, K. V., and Dieffenbach, C. W., 1991, Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J. Virol. 65: 6881–6891.PubMedGoogle Scholar