Specific Cleavage of 28S Ribosomal RNA in Murine Coronavirus-Infected Cells

  • Sangeeta Banerjee
  • Sungwhan An
  • Shinji Makino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)


Mouse hepatitis virus (MHV), a prototypic Coronavirus, causes gastrointestinal and upper respiratory tract illnesses in animals and man. The 32 kb-long MHV genome is a positive-sense, single-stranded RNA (Lai et al 1981, Lee et al 1991) that encodes 11 open reading frames, expressed through the production of a genomic-size and six to eight species of subgenomic mRNAs (Lai et al 1981). Genomic-size mRNA encodes the 5’-most 22 kb-long gene 1, which encodes the RNA Polymerase function (Lee et al 1991). MHV contains three envelope proteins, S, M and E proteins. S protein binds to the Coronavirus receptor (Dveskler et al 1991). M and E proteins are important for the formation of the MHV envelope (Kim et al 1997).


Mouse Hepatitis Virus Respiratory Tract Illness Host Protein Synthesis Subgenomic mRNAs Viral RNase 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Sangeeta Banerjee
    • 1
    • 2
  • Sungwhan An
    • 1
  • Shinji Makino
    • 1
    • 2
  1. 1.Department of Microbiology and Institute of Cellular and Molecular BiologyThe University of Texas at AustinAustinUSA
  2. 2.Department of Microbiology and ImmunologyThe University of Texas Medical BranchGalvestonUSA

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