Induction of Apoptosis in Murine Coronavirus-Infected 17CI-1 Cells
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Apoptosis is an important process in the development and homeostasis of multicellular organisms (Jacobson et al 1997). In most cases, apoptosis is executed by activating a proteolytic system involving a family of caspases. Caspases participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in cell death (Cohen 1997). Apoptosis also represents a highly efficient defence mechanism against virus infection; apoptosis aids in removal of viral proteins and nucleic acids by the infected host.