A Virus-Neutralising Monoclonal Antibody Expressed in the Milk of Transgenic Mice

  • A. F. Kolb
  • J. Webster
  • C. B. A. Whitelaw
  • S. G. Siddell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)


Coronaviruses are frequently associated with respiratory and gastrointestinal disorders in both animals and man. In adult animals, Coronavirus infections are generally mild, however, in neonates they often cause severe and sometimes lethal diseases (Enjuanes and van der Zeijst, 1995). Maternal antibodies supplied via the placenta and milk efficiently protect new-born animals against the fatal consequences of acute coronaviral infections during this critical phase (Hornberger, 1992).


Transgenic Mouse Recombinant Antibody Trans Gene Heavy Chain Variable Region Antibody Light Chain 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • A. F. Kolb
    • 1
    • 2
  • J. Webster
    • 3
  • C. B. A. Whitelaw
    • 3
  • S. G. Siddell
    • 2
  1. 1.Hannah Research InstituteCell Physiology GroupAyrUK
  2. 2.Institute of VirologyUniversity of WürzburgWürzburgGermany
  3. 3.Division of Molecular BiologyRoslin InstituteRoslinUK

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