The Role of B Cells in Mouse Hepatitis Virus Infection and Pathology

  • Amy E. Matthews
  • Susan R. Weiss
  • Ehud Lavi
  • Mark Shlomchik
  • Yvonne Paterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)


Murine hepatitis virus (MHV) strain A59 infects the central nervous system (CNS) and liver of mice, causing encephalitis and hepatitis. Virus is cleared from both organs by 16 days post-infection (dpi) (Lavi et al, 1986; data not shown). Infection of the CNS by this virus is associated with demyelination. Interestingly, demyelination peaks at around 30 dpi, after infectious virus is cleared and only viral RNA and small amounts of protein remain (Lavi et al, 1984a, 1984b; Sutherland et al, 1997; data not shown).


Viral Titer Infectious Virus Viral Clearance Wildtype Mouse Mouse Hepatitis Virus 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Amy E. Matthews
    • 1
  • Susan R. Weiss
    • 1
  • Ehud Lavi
    • 2
  • Mark Shlomchik
    • 3
  • Yvonne Paterson
    • 1
  1. 1.Department of MicrobiologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of PathologyUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Laboratory Medicine and Section of ImmunobiologySchool of Medicine, Yale UniversityNew HavenUSA

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