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Caspase Inhibitors Block MHV-3 Induced Apoptosis and Enhance Viral Replication and Pathogenicity

  • Julian L. Leibowitz
  • Elena Belyavskaya
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Infection with mouse hepatitis virus strain 3 (MHV-3) results in lethal hepatitis in BALB/c mice, compared to the minimal disease observed in A/J mice (Levy, Leibowitz, and Edgington, 1981). The response of the macrophage to MHV infection is a key determinant of the outcome of MHV-induced hepatitis (Levy, Leibowitz, and Edgington, 1981; Shif and Bang, 1969). We have previously shown that infection of A/J macrophages with MHV-3 triggers apoptosis in most of the infected cells (Belyavskyi et al., 1998). In contrast, infection of BALB/c macrophages results in only a small percentage of the cells undergoing apoptosis. In this report we have utilized caspase inhibitors to investigate the hypothesis that the rapid induction of apoptosis in macrophages derived from A/J mice limits MHV replication and hepatic injury during MHV infection.

Keywords

Caspase Inhibitor Infected Macrophage Viral Yield Mouse Hepatitis Virus Murine Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Julian L. Leibowitz
    • 1
  • Elena Belyavskaya
    • 1
  1. 1.Department of Pathology and Laboratory MedicineTexas A&M University System Health Science CenterCollege StationUSA

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