The Severity of Hepatic Lesion after Intraperitoneal JHMV Infection in IFN-gamma Deficient Mice is Parallel to Viral Replication in Hepatocytes in Vitro
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Several factors affect MHV infection in mice (Table 1). They can be classified into two groups, viral factors and host factors. Although JHMV induces a fatal encephalitis in mice after intracerebral infection, it does a mild hepatitis when it is inoculated intraperitoneally. On the other hand, host genetic factor is a critical determinant. Among MHV researchers, it is well known that SJL mice are relatively resistant to intracerebral infection with JHMV (Stohlman & Frelinger 1978). In addition, the immune system is one of the key players that determine MHV infection in mice.