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The Severity of Hepatic Lesion after Intraperitoneal JHMV Infection in IFN-gamma Deficient Mice is Parallel to Viral Replication in Hepatocytes in Vitro

  • Shigeru Kyuwa
  • Seiji Kawamura
  • Shinwa Shibata
  • Kenji Machii
  • Yoh-Ichi Tagawa
  • Oichiroh Iwakura
  • Toru Urano
Chapter
  • 31 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Several factors affect MHV infection in mice (Table 1). They can be classified into two groups, viral factors and host factors. Although JHMV induces a fatal encephalitis in mice after intracerebral infection, it does a mild hepatitis when it is inoculated intraperitoneally. On the other hand, host genetic factor is a critical determinant. Among MHV researchers, it is well known that SJL mice are relatively resistant to intracerebral infection with JHMV (Stohlman & Frelinger 1978). In addition, the immune system is one of the key players that determine MHV infection in mice.

Keywords

Viral Titer Primary Hepatocyte Acute Hepatic Failure Mouse Hepatitis Virus Host Genetic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Shigeru Kyuwa
    • 1
  • Seiji Kawamura
    • 2
  • Shinwa Shibata
    • 3
  • Kenji Machii
    • 4
  • Yoh-Ichi Tagawa
    • 5
  • Oichiroh Iwakura
    • 3
  • Toru Urano
    • 1
  1. 1.Division of Microbiology and Genetics, Center for Animal Resources and DevelopmentKumamoto UniversityKumamotoJapan
  2. 2.Department of Biomedical Science, Faculty of AgricultureUniversity of TokyoTokyoJapan
  3. 3.Center for Experimental Medicine, Institute of Medical ScienceUniverisity of TokyoTokyoJapan
  4. 4.Department of Veterinary Public HealthInstitute of Public HealthTokyoJapan
  5. 5.Institute of Experimental AnimalsShinshu University Schoool of MedicineMatsumotoJapan

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