Analysis of CNS Inflammatory Responses to MHV
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Development of demyelination in the MHV system is associated with inflammatory cytokine responses in the brain. It is likely that these responses reflect the influx of T cells into the brain following infection. Previous work has described a central role for CD4+ T cells in viral clearance and subsequent demyelination (Lane, Liu et al. 1999; Lane, Liu et al. 2000; Wu, Dandekar et al. 2000). While CD8+ T cells are necessary for viral clearance, their involvement in demyelination is less defined (Castro, Evans et al. 1994; Stevenson, Belz et al. 1999). Glial cells have also been implicated in the disease process, contributing to cytokine production in the central nervous system (Sun, Grzybicki et al. 1995; Lane, Asensio et al. 1998).