Analysis of CNS Inflammatory Responses to MHV

Role of spike determinants in initiating chemokine and cytokine responses
  • Julia D. Rempel
  • Michael J. Buchmeier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)


Development of demyelination in the MHV system is associated with inflammatory cytokine responses in the brain. It is likely that these responses reflect the influx of T cells into the brain following infection. Previous work has described a central role for CD4+ T cells in viral clearance and subsequent demyelination (Lane, Liu et al. 1999; Lane, Liu et al. 2000; Wu, Dandekar et al. 2000). While CD8+ T cells are necessary for viral clearance, their involvement in demyelination is less defined (Castro, Evans et al. 1994; Stevenson, Belz et al. 1999). Glial cells have also been implicated in the disease process, contributing to cytokine production in the central nervous system (Sun, Grzybicki et al. 1995; Lane, Asensio et al. 1998).


Viral Clearance RNase Protection Assay Central Nervous System Inflammation Mouse Hepatitis Virus Spike Protein 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Julia D. Rempel
    • 1
  • Michael J. Buchmeier
    • 1
  1. 1.The Scripps Research InstituteLa JollaUSA

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