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Radiation Risks from p-Boronophenylalanine-Mediated BNCT for Glioblastoma Multiforme

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Frontiers in Neutron Capture Therapy

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Abstract

Boron neutron capture therapy (BNCT) is a binary treatment modality that requires selective delivery of a 10B-labeled compound to a tumor and slow neutron irradiation of the tumor-bearing tissues. The capture of thermalized neutrons by 10B releases high linear-energy-transfer (LET) alpha (α) and 7Li particles via the 10B(n,α)7Li reaction. These particles can kill or render non-clonogenic 10B-rich tumor cells while sparing boron-poor tissues. A phase I/II clinical trial of p-boronophenylalanine (≥95% 10B enriched)-mediated BNCT for GBM is being conducted using the Brookhaven Medical Research Reactor’s clinical epithermal neutron irradiation facility.

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Author information

Authors and Affiliations

  1. Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA

    R. Ma, J. Capala, J. Coderre, A. Z. Diaz, D. Greenberg, D. N. Slatkin & A. D. Chanana

  2. Department of Neurological Surgery, University of California-Davis, Sacramento, CA, 95817, USA

    H. B. Liu

  3. McClellan Nuclear Radiation Center, McClellan AFB, CA, 95652, USA

    H. B. Liu

Authors
  1. R. Ma
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  2. J. Capala
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  3. J. Coderre
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  4. A. Z. Diaz
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  5. D. Greenberg
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  6. H. B. Liu
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  7. D. N. Slatkin
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  8. A. D. Chanana
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Editor information

Editors and Affiliations

  1. University of California, Los Angeles, Los Angeles, California, USA

    M. Frederick Hawthorne  & Kenneth Shelly  & 

  2. Neutron Therapies LLC, San Diego, California, USA

    Richard J. Wiersema

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© 2001 Springer Science+Business Media New York

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Ma, R. et al. (2001). Radiation Risks from p-Boronophenylalanine-Mediated BNCT for Glioblastoma Multiforme. In: Hawthorne, M.F., Shelly, K., Wiersema, R.J. (eds) Frontiers in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1285-1_80

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  • DOI: https://doi.org/10.1007/978-1-4615-1285-1_80

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5478-9

  • Online ISBN: 978-1-4615-1285-1

  • eBook Packages: Springer Book Archive

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