Neural Mediation of Memory for Time

Role of the Hippocampus and Medial Prefrontal Cortex
  • Raymond P. Kesner

Abstract

The structure and utilization of memory is central to one’s knowledge of the past, interpretation of the present, and prediction of the future. Therefore, the understanding of the structural and process components of memory systems at the psychological and neurobiological level is of paramount importance. In recent years, there have been a number of attempts to divide learning and memory into multiple memory systems. Schacter and Tulving (1994) have suggested that one needs to define memory systems in terms of the kind of information to be represented, the processes associated with the operation of each system, and the neurobiological substrates including neural structures and mechanisms that subserve each system. Furthermore, it is likely that within each system there are multiple forms or subsystems associated with each memory system and there are likely to be multiple processes that define the operation of each system. Finally, there are probably multiple neural structures that form the overall substrate of a memory system.

Keywords

Prefrontal Cortex Memory System Entorhinal Cortex Temporal Order Medial Prefrontal Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baker, S.C., Rogers, R.D., Owen, A.M., Frith, CD., Dolan, R.J, Frackowiak, R.S.J, & Robbins, T.W. (1996). Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia, 34, 515–526.PubMedCrossRefGoogle Scholar
  2. Barker, D.J. (1967). Alterations in sequential behavior of rats following ablation of midline limbic cortex. Journal of Comparative and Physiological Psychology, 3, 453–604.CrossRefGoogle Scholar
  3. Block, R.A. (1990). Models of psychological time. In R.A. Block (Ed.), Cognitive models of psychological time (pp. 1–36). Hillsdale, NJ: Lawrence Erlbaum.Google Scholar
  4. Chiba, A.A., Johnson, D.L, & Kesner, R.P. (1992). The effects of lesions of the dorsal hippocampus or the ventral hippocampus on performance of a spatial location order recognition task. Society for Neuroscience Abstracts, 18, 1422.Google Scholar
  5. Chiba, A.A., Kesner, R.P, Matsuo, F, & Heilbrun, M.P. (1993). A dissociation between affect and recognition following unilateral temporal lobectomy including the amygdala. Society for Neuroscience Abstracts, 19, 792.Google Scholar
  6. Chiba, A.A., Kesner, R.P., Matsuo, F, Heilbrun, M.P., & Plumb, S. (Submitted). A double dissociation between the right and left hippocampus in processing the temporal order of spatial and verbal information.Google Scholar
  7. Chiba, A.A., Kesner, R.P., & Reynolds, A.M. (1994). Memory for spatial location as a function of temporal lag in rats: Role of hippocampus and medial prefrontal cortex. Behavioral and Neural Biology, 61, 123–131.PubMedCrossRefGoogle Scholar
  8. Cho, Y.H., Beracochea, D., & Jaffard, R. (1993). Extended temporal gradient for retrograde and anterograde amnesia produced by ibotenate entorhinal cortex lesions in mice. Journal of Neuroscience, 13, 1759–1766.PubMedGoogle Scholar
  9. Cho, Y.H., & Kesner, R.P. (1996). Involvement of entorhinal cortex or parietal cortex in long-term spatial discrimination memory in rats: Retrograde amnesia. Behavioral Neuroscience, 110, 436–442.PubMedCrossRefGoogle Scholar
  10. Cho, Y.H., Kesner, R.P., & Brodale, S. (1995). Retrograde and anterograde amnesia for spatial discrimination in rats: Role of hippocampus, entorhinal cortex and parietal cortex. Psychobiology, 23, 185–194.Google Scholar
  11. Cohen, N.J. & Eichenbaum, H.B. (1993). Memory, Amnesia, and Hippocampal Function. Cambridge, MA: The MIT Press.Google Scholar
  12. DeRenzi, E. (1982). Disorders of space exploration and cognition. New York: Wiley.Google Scholar
  13. DiMattia, B.V., & Kesner, R.P. (1988). Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation. Behavioral Neuroscience, 102, 471–480.PubMedCrossRefGoogle Scholar
  14. Disterhoft, J.F., Carrillo, M.C., Hopkins, R.O., Gabrieli, J.D.E., & Kesner, R.P. (1996). Impaired trace eyeblink conditioning in severe medial temporal lobe amnesics. Society for Neuroscience Abstracts, 22, 1866.Google Scholar
  15. Estes, W.K. (1986). Memory for temporal information. In J.A. Michon & J.L. Jackson (Eds.), Time, mind and behavior (pp. 151–168). New York: Springer-Verlag.Google Scholar
  16. Funahashi, S., Inoue, M., & Kubota, K. (1997). Delay-period activity in the primate prefrontal cortex encoding multiple spatial positions and their order of presentation. Behavioural Brain Research, 84, 203–223.PubMedCrossRefGoogle Scholar
  17. Fuster, J.M. (1980). _The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe. New York: Raven.Google Scholar
  18. Fuster, J.M. (1985). The prefrontal cortex, mediator of cross-temporal contingencies. Human Neurobiology, 4, 169–179.PubMedGoogle Scholar
  19. Fuster, J.M. (1995). Memory in the cerebral cortex: An empirical approach to neural networks in the human and nonhuman primate. Cambridge, MA: The MIT Press.Google Scholar
  20. Fuster, J.M., Bauer, R.H, & Jervey, J.P. (1982). Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks. Experimental Neurology, 11, 679–694.CrossRefGoogle Scholar
  21. Gibbon, J., Malapani, C., Dale, C.L., & Gallistel, C.R. (1997). Toward a neurobiology of temporal cognition: Advances and challenges. Current Opinion in Neurobiology, 1, 170–184.CrossRefGoogle Scholar
  22. Heindel, W., Butters, N., & Salmon, D. (1988). Impaired learning of a motor skill in patients with Huntington’s disease. Behavioral Neuroscience, 102, 141–147.PubMedCrossRefGoogle Scholar
  23. Hintzman, D.L., Grandy, C.A., & Gold, E. (1981). Memory for frequency: A comparison of two multiple trace theories. Journal of Experimental Psychology: Human Learning and Memory, 7, 231–240.CrossRefGoogle Scholar
  24. Hintzman, D.L., Nozawa, G., & Irmscher, M. (1982). Frequency as a nonpropositional attribute of memory. Journal of Verbal Learning and Verbal Behavior, 21, 127–141.CrossRefGoogle Scholar
  25. Hirst, W., & Volpe, B. (1982). Temporal order judgments with amnesia. Brain and Language, 1, 294–306.Google Scholar
  26. Hopkins, R.O., & Kesner, R.P. (1994). Short-term memory for duration in hypoxic subjects. Society for Neuroscience Abstracts, 20, 1075.Google Scholar
  27. Hopkins, R.O., & Kesner, R.P. (1995). Item and order recognition memory in subjects with hypoxic brain injury. Brain and Cognition, 27, 180–201.PubMedCrossRefGoogle Scholar
  28. Hopkins, R.O., Kesner, R.P., & Goldstein, M. (1995a). Item and order recognition memory for words, pictures, abstract pictures, spatial locations, and motor responses in subjects with hypoxic brain injury. Brain and Cognition, 27, 180–201.CrossRefGoogle Scholar
  29. Hopkins, R.O., Kesner, R.P., & Goldstein, M. (1995b). Memory for novel and familiar spatial and linguistic temporal distance information in hypoxic subjects. Journal of the International Neuropsychological Society, 1, 454–468.CrossRefGoogle Scholar
  30. Horel, J.A., Pytko-Joiner, D.E., Voytko, M.L., & Salsbury, K. (1987). The performance of visual tasks while segments of the inferotemporal cortex are suppressed by cold. Behavioral Brain Research, 23, 29–42.CrossRefGoogle Scholar
  31. Huppert, F., & Piercey, M. (1976). Recognition memory in amnesic patients: Effects of temporal context and familiarity of material. Cortex, 4, 3–28.Google Scholar
  32. Jackson-Smith, P., Kesner, R.P., & Amann, K. (1994). Effects of hippocampal and medial prefrontal lesions on discrimination of duration in rats. Society for Neuroscience Abstracts, 20, 1210.Google Scholar
  33. Jurado, M.A., Junque, C., Pujol, J., Oliver, B., & Vendrell, P. (1997). Impaired estimation of word occurrence frequency in frontal lobe patients. Neuropsychologia, 35, 635–641.CrossRefGoogle Scholar
  34. Kametani, H., & Kesner, R.P. (1989). Retrospective and prospective coding of information: Dissociation of parietal cortex and hippocampal formation. Behavioral Neuroscience, 103, 84–89.PubMedCrossRefGoogle Scholar
  35. Kesner, R.P. (1989). Retrospective and prospective coding of information: Role of the medial prefrontal cortex. Journal of Experimental Brain Research, 74, 163–167.Google Scholar
  36. Kesner, R.P. (1990a). Learning and memory in rats with an emphasis on the role of the hippocampal formation. In Kesner, R.P. & Olton, D.S. (Eds.), Neurobiology of comparative cognition (pp. 179–204). Hillsdale, NJ: Erlbaum.Google Scholar
  37. Kesner, R.P. (1990b). Memory for frequency in rats: Role of the hippocampus and medial prefrontal cortex. Behavioral and Neural Biology, 53, 402–410.CrossRefGoogle Scholar
  38. Kesner, R. P. (1998). Neurobiological views of memory. In J. L. Martinez & R. P. Kesner (Eds.), The Neurobiology of Learning and Memory. Academic Press: San Diego, CA, 361–416.CrossRefGoogle Scholar
  39. Kesner, R.P., Bolland, B.L., & Dakis, M. (1993). Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Experimental Brain Research, 93, 462–470.CrossRefGoogle Scholar
  40. Kesner, R.P., & DiMattia, B.V. (1987). Neurobiology of an attribute model of memory. Progress in Psychobiology and Physiological Psychology. New York: Academic Press.Google Scholar
  41. Kesner, R.P., & Holbrook, T. (1987). Dissociation of item and order spatial memory in rats following medial prefrontal cortex lesions. Neuropsychologia, 25, 653–664.PubMedCrossRefGoogle Scholar
  42. Kesner, R.P., Hopkins, R.O., & Fineman, B. (1994). Item and order dissociation in humans with prefrontal cortex damage. Neuropsychologia, 32, 881–891.PubMedCrossRefGoogle Scholar
  43. Kesner, R.P., & Novak, J. (1982). Serial position curve in rats: Role of the dorsal hippocampus. Science, 218, 173–174.PubMedCrossRefGoogle Scholar
  44. Kesner, R.P., & Wilburn, M.W. (1974). A review of electrical stimulation of the brain in context of learning and retention. Behavioral Biology, 10, 259–293.PubMedCrossRefGoogle Scholar
  45. Kesner, R.P., & Williams, J.M. (1995). Memory for magnitude of reinforcement: Dissociation between the amygdala and hippocampus. Neurobiology of Learning and Memory, 64, 237–244.PubMedCrossRefGoogle Scholar
  46. Kesner, R. P., & Hopkins, R. O. (2001). Short-term memory for duration and distance in humans: Role of the hippocampus. Neuropsychology, 15, 58–68.PubMedCrossRefGoogle Scholar
  47. Kim, J.J., Clark, R.E., & Thompson, R.F. (1995). Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. Behavioral Neuroscience, 109, 195–203.PubMedCrossRefGoogle Scholar
  48. Kim, J.J., & Fanselow, M.S. (1992). Modality-specific retrograde amnesia of fear. Science, 256, 675–677.PubMedCrossRefGoogle Scholar
  49. Kojima, S., Matsumura, M., & Kubota, K. (1981). Prefrontal neuron activity during delayed-response performance without imperative GO signals in the monkey. Experimental Neurology, 74, 396–407.CrossRefGoogle Scholar
  50. Kolb, B. (1974). Social behavior of rats with chronic prefrontal lesions. Physiological Psychology, 87, 466–474.CrossRefGoogle Scholar
  51. Kolb, B., & Milner, B. (1981). Performance of complex arm and facial movements after focal brain lesions. Neuropsychologia, 19, 491–504.PubMedCrossRefGoogle Scholar
  52. Leonard, G., & Milner, B. (1991). Contribution of the right frontal lobe to the encoding and recall of kinesthetic distance information. Neuropsychologic 29, 47–58.CrossRefGoogle Scholar
  53. Lewinsohn, P.M., Zieler, J.L., Libet, J., Eyeberg, S., & Nielson, G. (1972). Short-term memory: A comparison between frontal and nonfrontal right- and left-hemisphere brain-damaged patients. Journal of Comparative and Physiological Psychology, 81, 248–255.PubMedCrossRefGoogle Scholar
  54. Madigan, S.A. (1969). Intraserial repetition and coding processes in free recall. Journal of Verbal Learning and Verbal Behavior, 8, 828–835.CrossRefGoogle Scholar
  55. Maren, S., Aharonov, G., & Fanselow, M.S. (1996). Excitotoxic dorsal hippocampus lesions and Pavlovian fear conditioning in rats. Society for Neuroscience Abstracts, 22, 1379.Google Scholar
  56. Markowitsch, H.J. (1995). Which brain regions are critically involved in the retrieval of old episodic memory? Brain Research Reviews, 21, 117–127.PubMedCrossRefGoogle Scholar
  57. McDonald, R.J., & White, N.M. (1993). A triple dissociation of systems: hippocampus, amygdala, and dorsal striatum. Behavioral Neuroscience, 107, 3–22.PubMedCrossRefGoogle Scholar
  58. Meek, W.H., Church, R.M., & Olton, D.S. (1984). Hippocampus, time and memory. Behavioral Neuroscience, 98, 3–22.CrossRefGoogle Scholar
  59. Milner, B. (1964). Some effects of frontal lobectomy in man. In J.M. Warren, & K. Akert (Eds.), The Frontal Granular Cortex and Behavior (pp. 313–334). New York: McGraw-Hill.Google Scholar
  60. Milner, B. (1971). Interhemispheric differences in the localization of psychological processes in man. British Medical Bulletin, 21, 272–277.Google Scholar
  61. Milner, B., Petrides, M., & Smith, M.L. (1985). Frontal lobes and the temporal organization of memory. Human Neurobiology, 4, 137–142.PubMedGoogle Scholar
  62. Morris, R.G., Ahmed, S., Syed, G.M., & Toone, B.K. (1993). Neural correlates of planning ability: Frontal lobe activation during the Tower of London test. Neurophsychologia, 31, 1367–1378.CrossRefGoogle Scholar
  63. Moyer, J.R. Jr., Deyo, R.A., & Disterhoft, J.F. (1990). Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral Neuroscience, 104, 243–252.PubMedCrossRefGoogle Scholar
  64. Mumby, D.G., Wood, E.R., & Pinel, J.P.J. (1992). Object recognition memory is only mildly impaired in rats with lesions of the hippocampus and amygdala. Psychobiology, 20, 18–27.Google Scholar
  65. Nadel, L. & Moscovitch, M. (1997). Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinion in Neurobiology, 7, 217–227.PubMedCrossRefGoogle Scholar
  66. Niki, H. (1974a). Prefrontal unit activity during delayed alternation in the monkey. I. Relation to direction of response. Brain Research, 68, 185–196.CrossRefGoogle Scholar
  67. Niki, H. (1974b). Prefrontal unit activity during delayed alternation in the monkey. II. Relation to absolute versus relative direction of response. Brain Research, 68, 185–196.CrossRefGoogle Scholar
  68. O’Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. Oxford: Clarendon Press.Google Scholar
  69. Olton, D.S. (1983). Memory functions and the hippocampus. In W. Seifert (Ed.), Neurobiology of the Hippocampus. New York: Academic Press.Google Scholar
  70. Olton, D.S. (1986). Hippocampal function and memory for temporal context. In R.L. Isaacson & K.H. Pribram (Eds.), The Hippocampus, Vol.3. New York: Plenum Press.Google Scholar
  71. Olton, D.S., Wenk, G.L., Church, R.M., & Meek, W.H. (1988). Attention and the frontal cortex as examined by simultaneous temporal processing. Neuropsychologia, 26, 307–318.PubMedCrossRefGoogle Scholar
  72. Otto T, & Eichenbaum, H. (1992). Complementary roles of the orbital prefrontal cortex and the perirhinal-entorhinal cortices in an odor-guided delayed-nonmatching-to-sample task. Behavioral Neuroscience, 106, 762–775.PubMedCrossRefGoogle Scholar
  73. Owen, A.M., Downes, J.J., Sahakian, B.J., Polkey, C.E., & Robbins, T.W. (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia, 28, 1021–1034.PubMedCrossRefGoogle Scholar
  74. Passingham, R. (1978). Information about movements in monkeys (Macaca mulatta) with lesions of dorsal prefrontal cortex. Brain Research, 152, 313–328.PubMedCrossRefGoogle Scholar
  75. Petrides, M., & Milner, B. (1982). Deficits on subject-ordered task after frontal- and temporal-lobe lesions in man. Neuropsychologia, 20, 249–262.PubMedCrossRefGoogle Scholar
  76. Pribram, K.H., & Tubbs, W.E. (1967). Short-term memory, parsing, and the primate frontal cortex. Science, 156, 1765–1767.PubMedCrossRefGoogle Scholar
  77. Sagar, H.J., Gabrieli, J.D.E., Sullivan, E.V., & Corkin, S. (1990). Recency and frequency discrimination in the amnesic patient H.M. Brain, 113, 581–602.PubMedCrossRefGoogle Scholar
  78. Santi, A., Weise, L., & Kuiper, D. (1995). Memory for event duration in rats. Learning and Motivation, 26, 83–100.CrossRefGoogle Scholar
  79. Schacter, D.L. (1987). Implicit memory: History and current status. Journal of Experimental Psychology: Learning, Memory, and Cognition, 13, 501–518.CrossRefGoogle Scholar
  80. Schacter, D.L., & Tulving, E. (1994). Memory Systems 1994. Cambridge, MA: The MIT Press.Google Scholar
  81. Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London B, 298, 199–209.CrossRefGoogle Scholar
  82. Slotnick, B.M. (1967). Disturbances of maternal behavior in the rat following lesions of the cingulate cortex. Behavior, 29, 204–236.CrossRefGoogle Scholar
  83. Squire, L.R. (1994). Declarative and nondeclarative memory: Multiple brain systems supporting learning and memory. In D.L. Schacter & E. Tulving (Eds.), Memory Systems 1994 (pp. 203–231). Cambridge, MA: The MIT Press.Google Scholar
  84. Squire, L., Nadel, L., & Slater, P. (1981). Anterograde amnesia and memory for temporal order. Neuropsychologia, 19, 141–146.PubMedCrossRefGoogle Scholar
  85. Stamm, J.S. (1955). The function of the median cerebral cortex in maternal behavior of rats. Journal of Comparative and Physiological Psychology, 48, 347–356.PubMedCrossRefGoogle Scholar
  86. Tulving, E. (1983). Elements of Episodic Memory. Oxford: Clarendon Press.Google Scholar
  87. Weisend, M.P., Astur, R.S., & Sutherland, R.J. (1996). The specificity and temporal characteristics of retrograde amnesia after hippocampal lesions. Society for Neuroscience Abstracts, 22, 1118.Google Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Raymond P. Kesner
    • 1
  1. 1.University of UtahUSA

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