Metabolism and Transport of Purinergic Receptor Agonists in Rabbit Conjunctival Epithelial Cells

  • Hovhannes J. Gukasyan
  • Benjamin R. Yerxa
  • William Pendergast
  • Vincent H. L. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


The role of extracellular nucleotides as signaling molecules is well established in a number of biological systems. Their function in the regulation of ion1, 2 and fluid3 transport has been investigated in the pigmented rabbit conjunctiva where active Cl secretion has been implicated as the driving force for fluid secretion.3 These agonists interact with two classes of receptors located on the cell membrane: P2X ligand-gated ion channels and P2Y G-protein-coupled receptors.4 Receptor mapping techniques have revealed the presence of P2Y type receptors in ocular epithelial cells.5


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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Hovhannes J. Gukasyan
    • 1
  • Benjamin R. Yerxa
    • 2
  • William Pendergast
    • 2
  • Vincent H. L. Lee
    • 1
  1. 1.Departments of Pharmaceutical Sciences and OphthalmologyUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Inspire PharmaceuticalsDurhamUSA

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