The Basal Ganglia VII pp 29-34 | Cite as
Synchronization of Pallidal Activity in The Mptp Primate Model of Parkinsonism is not Limited to Oscillatory Activity
Abstract
Early studies of the neuronal activity of basal ganglia neurons in the MPTP primate model of the disease (Miller and DeLong, 1987;Filion and Tremblay, 1991) and in human patients undergoing streotaxic surgeries (see reviews in (Lang and Lozano, 1998a;Lang and Lozano, 1998b;Vitek and Giroux, 2000)) focused on changes in the firing rates of these neurons. Firing patterns in the basal ganglia networks are also dramatically altered following MPTP-treatment. There is an increase in the percentage of neurons that discharge in bursts. These bursts are either irregular or oscillatory (periodic) and have been found in the striatum (Raz et al., 1996), STN (Bergman et al., 1994), GPe and GPi (Miller and DeLong, 1987;Filion and Tremblay, 1991;Boraud et al., 1998; Raz et al., 2000;Bergman et al., 1994;Nini et al., 1995;Wichmann et al., 1999) and recently also in primary motor cortex (Goldberg et. al, this volume). Physiological studies in human PD patients have found cells whose discharge is modulated in the tremor frequency range in the thalamus, in GPi and in the STN (Hutchison et al., 1997; Lenz et al., 1988; Magnin et al., 2000).
Keywords
Globus Pallidus Subthalamic Nucleus Globus Pallidus Internalis MPTP Treatment Neuronal SynchronizationPreview
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References
- Bar-Gad, I., Ritov, Y. and Bergman, H., 2001, Failure in identification of overlappig spikes from multiple neuron activity causes artificial correlationsJ Neurosci Methods107:1–13.PubMedCrossRefGoogle Scholar
- Bergman, H., Feingold, A., Nini, A., Raz, A., Slovin, H., Abeles, M. and Vaadia, E., 1998, Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primatesTrends Neurosci 21:32-38. PubMedCrossRefGoogle Scholar
- Bergman, H., Wichmann, T., Karmon, B. and DeLong, MR., 1994, The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonismJNeurophysiol72:507–520.Google Scholar
- Boraud, T., Bezard, E., Guehl, D., Bioulac, B. and Gross, C., 1998, Effects of L-DOPA on neuronal activity of the globus pallidus extemalis (GPe) and globus pallidus intemalis (GPi) in the MPTP-treated monkeyBrain Res787:157–160.PubMedCrossRefGoogle Scholar
- Filion, M. and Tremblay, L., 1991, Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonismBrain Res547:142–151.PubMedGoogle Scholar
- Hurtado, JM., Gray, CM., Tamas, LB. and Sigvardt, KA., 1999, Dynamics of tremor-related oscillations in the human globus pallidus: a single case study.Proc Natl Acad Sci USA96:1674–1679.PubMedCrossRefGoogle Scholar
- Hutchison, WD., Lozano, AM., Tasker, RR., Lang, AE. and Dostrovsky, JO., 1997, Identification and characterization of neurons with tremor-frequency activity in human globus pallidus.Exp Brain Res113:557–563.PubMedCrossRefGoogle Scholar
- Lang, AE. and Lozano, AM., 1998b, Parkinson’s disease. First of two partsN Engl J Med339:1044–1053.CrossRefGoogle Scholar
- Lang, AE. and Lozano, AM., 1998a, Parkinson’s disease. Second of two partsNEngl JMed339:1130–1143.CrossRefGoogle Scholar
- Lenz, FA., Tasker, RR., Kwan, HC., Schnider, S., Kwong, R., Murayama, Y., Dostrovsky, JO. and Murphy,JT., 1988, Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic“tremor cells” with the 3–6 Hz component of parkinsonian tremorJNeurosci8:754–764.Google Scholar
- Levy, R., Neuronal activity in the subthalamic nucleus and globus pallidus of patients with Parkinson’s disease,2001, PhD thesis, University of Toronto.Google Scholar
- Levy, R., Hutchison, WD., Lozano, AM. and Dostrovsky, JO., 2000, High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremorJ Neurosci20:7766–7775.PubMedGoogle Scholar
- Magnin, M., Morel, A. and Jeanmonod, D., 2000, Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patientsNeurosci96:549–564.CrossRefGoogle Scholar
- Miller, WC. and DeLong, MR., 1987, Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of parkinsonism. In: The Basal Ganglia II (Carpenter MB, Jayaraman A, eds), pp 415–427. New York: Plenum Press.CrossRefGoogle Scholar
- Nini, A., Feingold, A., Slovin, H. and Bergman, H., 1995, Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of parkinsonismJNeurophysiol 74:1800–1805.Google Scholar
- Raz, A., Feingold, A., Zelanskaya, V., Vaadia, E. and Bergman, H., 1996 Neuronal synchronization of tonically active neurons in the striatum of normal and parkinsonian primatesJNeurophysiol76:2083–2088.Google Scholar
- Raz, A., Frechter-Mazar, V., Feingold, A., Abeles, M., Vaadia, E. and Bergman, H., 2001, Activity of pallidal and striatal tonically active neurons is correlated in MPTP-treated monkeys but not in normal monkeys.J Neurosci21:RC128: 1–5.Google Scholar
- Raz,A., Vaadia, E. and Bergman, H., 2000, Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and the tremulous 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine vervet model of parkinsonismJNeurosci20:8559–8571.Google Scholar
- Vitek, J. and Giroux, M., 2000, Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesiaAnn Neurol47:5131–5140.Google Scholar
- Wichmann,T., Bergman, H., Starr, PA., Subramanian, T., Watts, RL. and DeLong, MR., 1999, Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primatesExp Brain Res125:397–409.CrossRefGoogle Scholar