Biological Reactive Intermediates VI pp 535-539

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 500)

Elevation of Glutathione Levels by Coffee Components and Its Potential Mechanisms

  • Gerlinde Scharf
  • Sonja Prustomersky
  • Wolfgang W. Huber


The tripeptide glutathione (L-γ-glutamyl-L-cysteinylglycine) is found ubiquitous in microorganisms, plants and animals. In mammalian cells, where the tripeptide fulfils numerous functions, concentrations range from 0.5 to 10 mM (Meister & Tate, 1976; Meister, 1984; Redegeld et al., 1990). Glutahione is involved, for example, in the synthesis of proteins and DNA, in the regulation of enzyme activity, in the transport and reservoir of amino acids. A very important function of glutathione is the protection of cells, for instance as an antioxidant or as a co-factor in the conjugation of xenobiotics (Meister & Anderson, 1983; Redegeld et al., 1990).


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Gerlinde Scharf
    • 1
  • Sonja Prustomersky
    • 1
  • Wolfgang W. Huber
    • 1
  1. 1.Institute of Cancer ResearchViennaAustria

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