New Selective Aminopeptidase N Inhibitors as Potential Therapeutics

  • Marie-Claude Fournié-Zaluski
  • Bernard P. Roques


Aminopeptidase N (EC, APN) is a monomeric or homodimeric type II membrane-bound zinc metallopeptidase initially identified by Pfleiderer and coworkers in pig kidney (Pfleiderer and Celliers, 1963; Wachsmuth et al 1966).


Boronic Acid Inhibitory Potency Neutral Endopeptidase Phosphinic Acid Transition State Analogue 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Marie-Claude Fournié-Zaluski
    • 1
  • Bernard P. Roques
    • 2
  1. 1.Département de Pharmacochimie Moléculaire et Structurale INSERM U266, CNRS UMR 8600UFR des Sciences Pharmaceutiques et biologiquesParis Cedex 06France
  2. 2.PHARMALEADSParis Cedex 06France

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