Skip to main content

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 16))

  • 169 Accesses

Abstract

Radio-telemetry of biological signals combines miniature sensors and miniature transmitting technology for transmitting biological signals to remote receivers. The receiver converts the radio frequency into a digital signal to measure e.g. blood pressure (BP), electrocardiogram (ECG), heart rate (HR), respiratory rate (RR) and body temperature. The signals from the receivers are transmitted to the data acquisition system. This system converts the signal into the desired format, such as beats per minute (bpm) for HR. As with all new technology, it is vital for scientists to remain sceptical and to demand validations of the new technology versus current conventional measurement techniques, to the fullest extent possible. New technologies, however, make it possible to perform measurements under conditions that have not previously been possible, thus making direct comparisons with current conventional measurement techniques sometimes impractical.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, N.H., Devlin, A.M., Graham, D., et al. Telemetry for cardiovascular monitoring in a pharmacological study. New approaches to data analysis. Hypert 33 (II): 248–255, 1999.

    Article  CAS  Google Scholar 

  2. Atannasov, P., Yang, S., Salehi, C., et al. Implantation of a refillable glucose monitoring-telemetry device.Biosen Bioelectr12 (7): 669–680, 1997.

    Article  Google Scholar 

  3. Balakrishnan, S. and McNeill, J.R. Cardiac output mediates the antihypertensive effect of vasopressin in spontaneous hypertension.JPhysio27: h1729-h1733, 1996.

    Google Scholar 

  4. Barone, F.C., Knudsen, D.J., Nelson, A.H., et al. Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy.J Cereb Blood Flow Metab13(4): 683–692, 1993.

    Article  PubMed  CAS  Google Scholar 

  5. Baumans, V., Bouwknecht, J.A., Boere, H., et al. Intra-abdominal transmitter implantation in mice: Effects on behaviour and body weight.Anim Welfare 10:291–302, 2001.

    Google Scholar 

  6. Bazil, M.K., Krulan, C. and Webb, R.L. Telemetric monitoring of cardiovascular parameters in conscious spontaneously hypertensive rats.J Cardiovasc Pharmacol22 (6): 897–905, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Brockway, B.P., Mills, P.A. and Azar, S.H. A new method for continuous chronic measurement and recording of blood pressure, heart rate, and activity in the rat via radiotelemetry.Clin Exp Hyper3 (5): 885–895, 1991.

    Article  Google Scholar 

  8. Brockway, B.P. and Hassler C.R. Application of radio telemetry to cardiovascular measurements in pharmacology and toxicology.New Technologies and Concepts for Reducing Drug Toxicity.Boca Raton: CRC Press, 1993, p. 109–132.

    Google Scholar 

  9. Brockway, R.V. and Huetteman, D.A.A new method for chronic measurement of respiratory rate in conscious freely moving rats. (“Abstract”) 50th AALAS National Meeting. Indianapolis1999, p. 28.

    Google Scholar 

  10. Brockway, R.V. and Huetteman. D.A.A new method for chronic measurement of respiratory rate in conscious freely moving mice. Personal Communication, Data Sciences International, St. Paul, Minnesota 55126, USA, 2001.

    Google Scholar 

  11. Brockway, R.V., Huetteman, D., Kuenzi, R. and Martin, L.Novel Method for sleep monitoring in freely moving mice. Personal Communication, Data Sciences International, St. Paul, Minnesota 55126, USA, 2002.

    Google Scholar 

  12. Broom, D.M. and Johnson, K.G. In:Stress and animal welfare.Ed: Broom, D.M., Chapman and Hall, London, 1993.

    Google Scholar 

  13. Butz, G.M. and Davisson, R.L. Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool.Physiol Genom5: 89–97, 2001.

    CAS  Google Scholar 

  14. Clement, J.G., Mills, P.A. and Brockway, B.P. Use of telemetry to record body temperature and activity in mice. J Pharmacol Meth 21: 129–140, 1989.

    Article  CAS  Google Scholar 

  15. Cotugno, M., Mandile, N., D’Angiolillo, D., et al. Implantation of an EEG telemetric transmitter in ther rat.Ital J Neurol Sci17: 131–134, 1996.

    Article  PubMed  CAS  Google Scholar 

  16. Davisson, R.L., Hoffmann, D.S., Butz, et al. Discovery of a spontaneous genetic mouse model of preeclampsia.Hypert39 (2): 337–342, 2002.

    Article  CAS  Google Scholar 

  17. Deveney, A.M., Kjellstrom, A. Forsberg, T., et al. A pharmacological validation of radiotelemetry in conscious freely moving rats.J Pharmacol Toxicol Meth40: 71–79, 1998.

    Article  CAS  Google Scholar 

  18. Doevendans, P.A., Daemen, M.J., et al. Cardiovascular phenotyping in mice.Cardiovasc Res39, 34–49, 1998.

    Article  PubMed  CAS  Google Scholar 

  19. Festing, M.F.W. The scope for improving the design of laboratory animal experiments.Lab Anim28: 212–221, 1992.

    Article  Google Scholar 

  20. Fewell, J.G., Osinska, H., Klevitsky, R., et al. A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice.Am J Physiol273 (42): H1595–H1605, 1997.

    PubMed  CAS  Google Scholar 

  21. Fraser, T.B., Tutner, S.W., Mangos, G.J, et al. Comparison of telemetric and tail-cuff pressure monitoring in adrenocorticotrophic hormone-treated rats.Clin Exp Pharmacol Physiol28 (10): 831–835, 2001.

    Article  PubMed  CAS  Google Scholar 

  22. Gehrmann, J., Hammer, P.E., Maguire, C.T., et al. Phenotypic screening for heart rate variabilty in the mouse. Am JPhysiol Heart Circ Physiol279 (2):H 733 — 740, 2000.

    Google Scholar 

  23. Gellai, M. and Valtin, H. Chronic vascular constriction and measurement of renal function in conscious rats.Kidney Int15: 419–426, 1979.

    Article  PubMed  CAS  Google Scholar 

  24. Gross, V., Milia, A.F., Plehm, R., et al. Long-term blood pressure telemetry in AT(2) receptor-disrupted mice.JHypert18 (7): 955–961, 2000.

    Article  CAS  Google Scholar 

  25. Harkin, A., Connor, T.J., O’Donnell, J.M. and Kelly, J.P. Physiological and Behavioral responses to stress: What does a rat find stressful?Lab Anim2 (4), 32–40, 2002.

    Google Scholar 

  26. Herd, J.A. Cardiovascular response to stress.Physiol Rev71 (1): 305–330, 1991.

    PubMed  CAS  Google Scholar 

  27. Hoit, B.D., Kiatchoosakun, S., Restivo, J., et al. Naturally occurring variation in cardiovascular traits among inbred mouse strains.Genom79 (5): 679–685, 2002.

    Article  CAS  Google Scholar 

  28. Itokawa, K., Sora, I., Schindler, C.W., et al. Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death.Mol Brain Res71 (2): 354–357, 1999.

    Article  PubMed  CAS  Google Scholar 

  29. James, J.F., Hewett, T.E. and Robbins, J. Cardiac physiology in transgenic mice.Circ Res82: 407–415, 1998.

    Article  PubMed  CAS  Google Scholar 

  30. Johansson, C., Gothe, S., Forrest, D., et al. Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha(1) and beta.Am J Physiol45 (6): H2006–H2012, 1999.

    Google Scholar 

  31. Kinter, L.B. Cardiovascular telemetry and laboratory animals welfare: New reduction and refinement alternatives. (“Abstract”)General Pharmacology/Safety Pharmacology MeetingPhiladelphia, PA. USA, 1996.

    Google Scholar 

  32. Kluger, M.J., Carole, A.C., Franklin, B., et al. Effect of gastrointestinal flora on body temperature of rats and mice.Am JPhysiol258 (27): R552–R557, 1990.

    CAS  Google Scholar 

  33. Kramer,K.,Van Acker, S.A.B.E., Voss, H.-P.,Grimbergen,J.A,et al. Use of telemetry to record electrocardiogram and heart rate in freely moving mice.J Pharmacol Toxicol Meth30(4):209–215,1993

    Article  CAS  Google Scholar 

  34. Kramer, K.Applications and evaluation of radio-telemetry in small laboratory animals. ThesisUniversity of Utrecht, The Netherlands, 2000.

    Google Scholar 

  35. Kramer, K., Kinter, L., Brockway, B.P., Voss, H.-P., Remie, R. and Van Zutphen, L.F.M.The use of radiotelemetry in small laboratory animals: Recent advances.Contemp Top Lab Anim Sci40 (1): 8–16, 2001.

    PubMed  CAS  Google Scholar 

  36. Kramer, K., Van de Weerd, H., Mulder, A., et al.Effect of conditioning on the increase of heart rate and body temperature provoked by handling in the mouse.ATLA Journal submitted,2002.

    Google Scholar 

  37. Krege, J.H., Hodgin, J.B., Hagaman, J.R.,et al. A noninvasive computerized tail-cuff system for measuring blood pressure in mice.Hypert25: 1111–1115, 1995.

    Article  CAS  Google Scholar 

  38. Lemmer, B., Mattes, A., Bohm, M. and Gante, D. Circadian blood pressure variation in transgenic hypertensive rats.Hypert22: 97–101, 1993.

    Article  CAS  Google Scholar 

  39. Lemmer, B. and Witte, K. Telemetric data acquisition of cardiovascular function in biology and pharmacology.In:Animal alternatives welfare and ethicsEds: Van Zutphen,L.F.M.Balls,M.Developments in animal and veterinary sciences,Vol 27, pp: 311–320,1997

    Google Scholar 

  40. Mansier, P., Medigue, C., Charlotte, N., et al. Decreased heart rate variability in transgenic mice overexpressing arterial f31-adrenoceptorsAm J Physiol271: H1465–H1572, 1996.

    Google Scholar 

  41. Mattes, A. and Lemmer, B. Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: A telemetric study in rats.Chronobiol Int8 (6): 526–538, 1991.

    Article  PubMed  CAS  Google Scholar 

  42. Mills, P.A., Huetteman, D.A., Brockway, B.P., et al. A new method for measurement of blood pressure, heart rate, and activity in the mouse by radiotelemetry.J Appl Physiol88 (5): 1537–1544, 2000.

    PubMed  CAS  Google Scholar 

  43. Mitchell, G.F., Jeron, A. and Koren, G. Measurement of heart rate and Q-T interval in the conscious mouse.Am JPhysiol274 (43): H747–H751, 1998.

    CAS  Google Scholar 

  44. O’Neil, P.J. and Kaufman, L.N. Effects of indwelling arterial catheters or physical restraint on food consumption and growth patterns of rats: Advantages of noninvasive blood pressure measurements techniques.Lab Anim Sci40: 641–643, 1990.

    Google Scholar 

  45. Paylor, R., Tracy, R., Wehner, J. and Rudy, J.W. DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning.Beh Neurosci108, 810–817, 1994.

    Article  CAS  Google Scholar 

  46. Saba, S., Wang, P.J. and Mark Estes III, N.A. Invasive cardiac electrophysiology in the mouse: Techniques and applications.Tr Cardiovasc Med10: 122–132, 2000.

    Article  CAS  Google Scholar 

  47. Sato, K., Chatani, F. and Sato, S. Circadian and short-term variabilities in blood pressure and heart rate measured by telemetry in rabbits and rats.J Auton Nery Sys54: 235–246, 1995.

    Article  CAS  Google Scholar 

  48. Schlingmann, F., Van de Weerd, H.A., Baumans, V., et al. A balance device for the analysis of behavioural patterns of the mouse.Anim Welfare7: 177–188, 1998.

    Google Scholar 

  49. Schnell, C.R. and Gerber, P. Training and remote monitoring of cardiovascular parameters in non-human primates.Primate Report49: 61–70, 1997.

    Google Scholar 

  50. Sgoifo, A., Stilli, D., Parmigiani, S., et al. Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained rats.Physiol Behav60 (6): 1397–1401, 1996.

    Article  PubMed  CAS  Google Scholar 

  51. Shusterman, V., Usiene, I., Harrigal, C., et al. Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice.Am J Physiol Heart Circ Physiol282: H2076–H2083, 2002.

    PubMed  CAS  Google Scholar 

  52. Stauss, H.M., Godecke, A., Mrowka, R., et al. Enhanced blood pressure variability in eNOS knockout mice.Hypert33 (6): 1359–1363, 1999.

    Article  CAS  Google Scholar 

  53. Stiedl, O. and Spiess, J. Effect of tone-dependent fear conditioning on heart rate and behaviour of C57BL/6N mice.Behav Neurosci111 (4), 703–711, 1997.

    Article  PubMed  CAS  Google Scholar 

  54. Stiedl, O., Radulovic, J., Lohmann, R., et al. Strain and substrain differences in context-and tone-dependent fear conditioning of inbred mice.Behav Brain Res104 (1–2), 1–12, 1999.

    Article  PubMed  CAS  Google Scholar 

  55. Til, H.P., Kuper, C.F. and Falke, H.E. Nitrite-induced adrenal effect in rats and the consequences for the no-observed-effect level.Food Chem Toxicol35: 349–355, 1997.

    Article  PubMed  CAS  Google Scholar 

  56. Uechi, M., Asai, K., Osaka, M., et al. Depressed heart rate variability and arterial baroflex in conscious transgenic mice with overexpression of cardiac (Gse).Circ Res82: 416–423, 1998.

    Article  PubMed  CAS  Google Scholar 

  57. Van Acker, S.A.B.E., Kramer, K., Grimbergen, J.A., et al. Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. A new model to test potential protectors.Canc Chemother Pharmacol38: 95–101, 1996.

    Article  Google Scholar 

  58. Van de Weerd, H.A. Environmental enrichment for laboratory mice: Preferences and consequences.ThesisUniversity of Utrecht, The Netherlands, 1996.

    Google Scholar 

  59. Vleeming, W., Van de Kuil, A., Te Biesebeek, J.D., et al. Effect of nitrite on blood pressure in anaesthetized and free-moving rats.Food Chem Toxicol35: 615–619, 1997.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kramer, K., Hachtman, S. (2004). Mouse Telemetry for Long-Term Monitoring. In: Ince, C. (eds) The Physiological Genomics of the Critically Ill Mouse. Basic Science for the Cardiologist, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0483-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0483-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5099-6

  • Online ISBN: 978-1-4615-0483-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics