Changing Partially Hydrogenated Fat for Palmitic Acid in the Diet Increases LDL-Cholesterol and Endogenous Cholesterol Synthesis in Normocholesterolemic Women

  • Margaret A. French
  • Kalyana Sundram
  • M. Thomas Clandinin
Chapter
Part of the Progress in Experimental Cardiology book series (PREC, volume 9)

Summary

The present studies assessed the effect of dietary intake of high versus low palmitic acid and the effect of exchanging palmitic acid for trans fatty acids on plasma lipoprotein cholesterol levels and on rates for endogenous synthesis of cholesterol in normal and hyper-lipidemic subjects. Healthy subjects received each of the diet treatments for 21 days, followed by washout periods of 21 days. On day 20 of each diet treatment, a priming dose of deuterium was consumed and was used to determine incorporation of deuterium into the newly synthesized cholesterol molecule, and fractional synthetic rates were calculated. The high level of 16:0 did not significantly affect serum total cholesterol and LDL-cholesterol when diets also contained a high level of 18:2n-6. The results indicate that 16:0 has no effect on serum lipoprotein profiles in the presence of recommended intakes for 18:2n-6. When the diet contained trans fatty acids total and LDL-cholesterol increased and cholesterol synthesis increased with a decrease in HDL-cholesterol.

Key words

palmitic acid trans fatty acids deuterium cholesterol 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Margaret A. French
    • 1
  • Kalyana Sundram
    • 2
  • M. Thomas Clandinin
    • 1
  1. 1.Nutrition and Metabolism Research Group Department of Agricultural, Food and Nutritional Science and Department of MedicineUniversity of AlbertaEdmontonCanada
  2. 2.Malaysian Palm Oil BoardSelangorMalaysia

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