ADP-Ribosylation and the Cardiovascular System

Chapter
Part of the Progress in Experimental Cardiology book series (PREC, volume 10)

Summary

Post-translational modification of proteins with ADP-ribose alters their physical and functional characteristics. The relationship between ADP-ribosylation and several bacterial toxins (e.g. cholera toxin, pertussis toxin, diphtheria toxin) is well established. In contrast, the function of the endogenous ADP-ribosyl transferase enzyme is poorly understood. The latter statement also applies to poly(ADP-ribose) polymerase, although PARP has become familiar due to its association with apoptosis. This article summarizes the enzymology of ADP-ribosylation, reviews the various cellular processes in which it may participate and examines the possible functions of ADP-ribosylation in cardiovascular tissues. Poly (ADP-ribosyl) ation, which has been linked to ischemia-reperfusion injury, is known to participate in DNA repair. In contrast, mono (ADP-ribosyl) ation is best known for modulating G protein function. In the cardiovascular system, mono(ADP-ribosyl)ation may exert effects by modifying growth factors or by transducing the intracellular effects of nitric oxide. Alternatively, mono (ADP-ribosyl) ation could influence cell migration by modifying cytoskeletal proteins. By also examining the role of ADP-ribosylation in other systems, considerable insight into the possible contributions of ADP-ribosylation to cardiovascular function can be extrapolated to both normal and pathological conditions.

Key words

ADP-ribosylation PARP ADP-ribosyl transferase cardiac vascular 
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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  1. 1.Institute of Cardiovascular SciencesSt. Boniface Research CentreWinnipegCanada
  2. 2.Department of PhysiologyUniversity of ManitobaCanada

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