Retinoid-Mediated Signaling and CD38 Expression

  • Kapil Mehta


CD38 was initially identified more than two decades back when murine monoclonal antibodies (mAbs) were being employed to define newer surface molecules expressed by the lymphocytes during various developmental stages. One such mAb (T10) was successfully employed in the analysis of distribution [1] and biochemical characterization of CD38 antigen [2]. The conclusions derived from the biochemical analysis of the molecule were independently confirmed by cloning of a cDNA for human CD38 in 1990 [3]. On the basis of its expression and allocation among immune cells, CD38 was referred to as an “activation marker” and till recently was used for phenotyping the differentiation state of lymphocytes and classifying leukemias.


Retinoic Acid CD38 Expression Acute Promyelocytic Leukemia CD38 Antigen CD38 Gene 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kapil Mehta
    • 1
  1. 1.Department of BioimmunotherapyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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