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Ca2+-Dependent Control of Rhodopsin Phosphorylation: Recoverin And Rhodopsin Kinase

  • Ivan I. Senin
  • Karl-Wilhelm Koch
  • Mohammad Akhtar
  • Pavel P. Philippov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 514)

Abstract

Over many years until the middle of the 1980s, the main problem in vision research had been the mechanism of transducing the visual signal from photobleached rhodopsin to the cationic channels in the plasma membrane of a photoreceptor to trigger the electrophysiological response of the cell. After cGMP was proven to be the secondary messenger, the main intriguing question has become the mechanisms of negative feedback in photoreceptors to modulate their response to varying conditions of illumination. Although the mechanisms of light-adaptation are not completely understood, it is obvious that Ca2+plays a crucial role in these mechanisms and that the effects of Ca2+can be mediated by several Ca2+-binding proteins. One of them is recoverin. The leading candidate for the role of an intracellular target for recoverin is believed to be rhodopsin kinase, a member of a family of G-protein-coupled receptor kinases. The present review considers recoverin, rhodopsin kinase and their interrelationships in the in vitro as well as in vivo contexts.

Keywords

Photoreceptor Cell Dependent Control Downstream Regulatory Element Antagonist Modulator Photoreceptor Membrane Neuronal Calcium Sensor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Ivan I. Senin
    • 1
  • Karl-Wilhelm Koch
    • 2
  • Mohammad Akhtar
    • 3
  • Pavel P. Philippov
    • 1
  1. 1.Department of Cell SignallingA.N.Belozersky Institute of Physico-Chemical Biology, Moscow State UniversityMoscowRussia
  2. 2.lnstitut für Biologische InformationsverarbeitungForschungszentrum Jülich GmbHJülichGermany
  3. 3.Division of Biochemistry and Molecular BiologySchool of Biological Sciences, University of Southampton, Basset Crescent EastSouthamptonUK

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