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XIAP Protects Photoreceptors from N-Methyl-N-Nitrosourea-Induced Retinal Degeneration

  • Dino Petrin
  • Adam Baker
  • Jennifer Brousseau
  • Stuart Coupland
  • Peter Liston
  • William W. Hauswirth
  • Robert G. Korneluk
  • Catherine Tsilfidis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 533)

Abstract

Retinitis Pigmentosa (RP) is a genetically heterogeneous disease that affects 1 in 3500 people globally (Pagon, 1988). Regardless of the causative mutation, the endpoint is the same; photoreceptor cell death occurs via apoptosis. The mechanisms that cause program cell death (PCD) in photoreceptors remain elusive. Anti-apoptotic strategies have shown promise as a therapeutic approach in the treatment of neurodegenerative diseases in animal models. Since the retina is of neuronal origin, it may be possible to treat RP by blocking the apoptotic cascade in photoreceptors, irrespective of the mutation involved, thereby delaying, if not preventing altogether, progression of the disease.

Keywords

Retinitis Pigmentosa Retinal Degeneration Outer Nuclear Layer rAAV Vector Subretinal Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Dino Petrin
    • 1
  • Adam Baker
    • 1
  • Jennifer Brousseau
    • 2
  • Stuart Coupland
    • 2
  • Peter Liston
    • 1
  • William W. Hauswirth
    • 3
  • Robert G. Korneluk
    • 1
  • Catherine Tsilfidis
    • 2
  1. 1.Children’s Hospital of Eastern Ontario Research InstituteOttawaCanada
  2. 2.University of Ottawa Eye InstituteOttawaCanada
  3. 3.University of Florida College of MedicineGainesvilleUSA

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