Histone Methylation in Chromatin Signaling
In this chapter we first provide a broad overview of some of the major discoveries that form the foundation of the histone methylation field. We then describe the main components involved in histone methylation signaling: the enzymes (“writers” and “erases”), the substrates, and the “readers,” and how together these components integrate to regulate critical nuclear and epigenetic programs. We also discuss how histone methylation is coordinated with DNA methylation, an important regulator of epigenetics. Finally, we describe some well-defined clinically important cases of histone methylation.
KeywordsHistone Methylation H3K9 Methylation Histone Demethylases Position Effect Variegation Histone Lysine Methylation
We thank Dr. Mark Bedford for providing critical advice and members of the Gozani and Shi labs for critical reading of the work. This work was supported in part by grants from the NIH to O. Gozani (R01 GM079641, R01CA172560) and to Y. Shi (RO1CA118487, RO1MH096006). O. Gozani and Y. Shi are recipients of an Ellison Senior Scholar in Aging Award. Y. Shi is an American Cancer Society Research Professor.