Histone Methylation in Chromatin Signaling

Chapter

Abstract

In this chapter we first provide a broad overview of some of the major discoveries that form the foundation of the histone methylation field. We then describe the main components involved in histone methylation signaling: the enzymes (“writers” and “erases”), the substrates, and the “readers,” and how together these components integrate to regulate critical nuclear and epigenetic programs. We also discuss how histone methylation is coordinated with DNA methylation, an important regulator of epigenetics. Finally, we describe some well-defined clinically important cases of histone methylation.

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of BiologyStanford UniversityStanfordUSA
  2. 2.Department of Cell BiologyHarvard Medical SchoolBostonUSA
  3. 3.Division of Newborn Medicine, Department of MedicineChildren’s Hospital, Harvard Medical SchoolBostonUSA

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