Archetypes and Outliers in the Neuromorphological Space

  • Cesar H. Comin
  • Julian Tejada
  • Matheus P. Viana
  • Antonio C. Roque
  • Luciano da F. CostaEmail author
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 11)


Neuromorphology has a long history of meticulous analysis and fundamental studies about the intricacies of neuronal shape. These studies converged to a plethora of information describing in detail many neuronal characteristics, as well as comprehensive data about cell localization, animal type, age, among others. Much of this information has notably been compiled through efforts of the Computational Neuroanatomy Group at the Krasnow Institute for Advanced Study, George Mason University, thus originating the repository, a resource that incorporates a large set of data and related tools. In the current work we present a methodology that can be used to search for novel relationships in cell morphology contained in databases such as the More specifically, we try to understand which morphological characteristics can be considered universal for a given cell type, or to what extent we can represent an entire cell class through an archetypal shape. This analysis is done by taking a large number of characteristics from cells into account, and then applying multivariate techniques to analyze the data. The neurons are then classified as archetypes or outliers according to how close they are to the typical shape of the class. We find that granule and medium spiny neurons can be associated with a typical shape, and that different animals and brain regions show distinct distributions of shapes.


Morphology Shape and function PCA projection 



 CHC is grateful to FAPESP (2011/22639-8 and 2011/50761-2) for sponsorship. JT is grateful to CNPq (560353/2010-3) and FAPESP (2012/17057-2) for a postdoctoral scholarship. MPV thanks to FAPESP for financial support (2010/16310-0). ACR is grateful to CNPq (306040/2010-7) for financial support. LdFC is grateful to FAPESP (05/00587- 5 and 2011/50761-2) and CNPq (301303/06-1 and 573583/2008-0) for the financial support.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Cesar H. Comin
    • 1
  • Julian Tejada
    • 2
  • Matheus P. Viana
    • 1
  • Antonio C. Roque
    • 2
  • Luciano da F. Costa
    • 1
    Email author
  1. 1.Institute of Physics at Sao CarlosSao CarlosBrazil
  2. 2.Department of Physics, School of Philosophy, Science and Letters of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

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