Noct’ Out

Fatal Forty DDI: chloral hydrate, phenobarbital, furosemide
Chapter

Abstract

This case discusses a complex interaction involving chloral hydrate. A synergistic pharmacodynamics interaction occurred between chloral hydrate and other sedatives. A protein-binding displacement reaction between chloral hydrate and furosemide also occurred.

Keywords

Pharmacodynamic Synergy Synergistic Chloral hydrate Sedation Benzodiazepines Phenobarbital Sedatives Protein binding Protein binding displacement Furosemide Warfarin Toxicity Sympathetic nervous system Sympathetic discharge Pharmacokinetic Distribution Thyroxine Albumin Barbiturates 
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Anesthesiology and Perioperative MedicineOregon Health and Science UniversityPortlandUSA

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