Nicardipine Notes

Fatal Forty DDI: nicardipine, tacrolimus, CYP3A4
  • Nenna NwazotaEmail author
  • Randal O. Dull


This case discusses an interaction between tacrolimus and nicardipine. Tacrolimus is a cytochrome P450 3A4 substrate and nicardipine is a 3A4 inhibitor. The interaction resulted in tacrolimus toxicity. The pharmacokinetics of nicardipine are also discussed.


Pharmacokinetic Inhibition Inhibitor CYP3A CYP3A4 CYP3A5 3A 3A4 3A5 Cytochrome P450 Transplant Immunosuppressant Tacrolimus Nicardipine Nifedipine Dihydropyridine calcium channel antagonist Calcineurin inhibitor Therapeutic drug monitoring 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnethesiologyBaylor College of MedicineHoustonUSA
  2. 2.Department of AnesthesiologyUniversity of Illinois at ChicagoChicagoUSA

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