Carotid Plaque Stress Analysis: Issues on Patient-Specific Modeling

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Abstract

Plaque stress analysis has been widely studied for understanding the mechanism of plaque initiation, development, and rupture. With development of computational power and medical imaging technique, plaque stress analysis has evolved from simplified 2D idealized mathematical model to much more complex model with 3D patient-specific structure. In this chapter, two issues regarding patient-specific plaque stress analysis have been studied: (1) patient-specific geometry and (2) patient-specific material properties. By using multispectral carotid MRI, 3D plaque geometries were reconstructed for one symptomatic patient and one asymptomatic patient with multicomponents, the followed plaque stress analysis showed plaque stress in the symptomatic patient had much higher value than that in the asymptomatic patient. Furthermore by analyzing carotid artery motion in one cardiac cycle, an anisotropic material model was fitted to the motion pattern of the selected carotid artery section. Then the fitted patient-specific material model was successfully applied to plaque stress analysis for the corresponding plaque sample. It is believed that plaque stress analysis with patient-specific modeling will be helpful in the identification of high-rupture risk patients.

Keywords

Carotid Plaque Lipid Core Stretch Ratio Fluid Structure Interaction Simulation Plaque Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

This project is supported by the British Heart Foundation (FS/06/048). The authors like to thank Dr ZY Li, Dr M Graves, M.D. JH Gillard from Department of Radiology, Cambridge University, for their contributions to all MR images, and collaborations in the project.

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.School of Mathematics and StatisticsUniversity of GlasgowGlasgowUK
  2. 2.Brunel Institute for BioengineeringBrunel UniversityLondonUK

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