Cortical Mapping of 3D Optical Topography in Infants
Precise localisation of cortical activation in the early development of the infant brain remains unclear. It is challenging to co-register haemodynamic responses during functional activation in infants with the underlying anatomy of the brain. We used a multispectral imaging algorithm to reconstruct 3D optical topographic images of haemodynamic responses in an infant during voice processing. In this chapter, we present a method for co-registering 3D optical topography images reconstructed from functional activation data in infants onto anatomical brain images obtained from MRI structurals of the individual infants.
KeywordsHaemodynamic Response Chromophore Concentration Finite Element Method Mesh Optical Topography Voice Processing
This work was supported by a grant from the Simons Foundation (SFARI 201287 M.J) and the National Institutes of Health, NICHD, R37 HD19842.