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Cancer Stem Cells in Resistance to Cytotoxic Drugs: Implications in Chemotherapy

  • Man-Tzu Wang
  • Hongmei Jiang
  • Debasish Boral
  • Daotai Nie
Chapter
Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 1)

Abstract

The efficacy of cytotoxic chemotherapy is limited by drug resistance presented by some cancer cells. Cancer stem cells (CSCs) are a sub-population of tumor cells that can initiate tumor formation. If chemotherapy kills bulk of cells within a tumor but not CSCs, the surviving CSCs can initiate the formation of recurrent tumors. This article discusses the inherent resistance of CSCs toward cytotoxic chemotherapy and some possible mechanisms involved. Approaches to target CSCs to improve the efficacy of chemotherapy will also be discussed.

Keywords

Cancer stem cells Drug resistance Multidrug resistance ATP binding cassette transporters Quiescence Cell survival Nanog 

Abbreviations

ABC

ATP binding cassette

ALDH

Aldehyde dehydrogenase

BCRP

Breast cancer resistance protein

CSCs

Cancer stem cells

EGFR

Epidermal growth factor receptor

ESC

Embryonic stem cells

LRCs

Label retaining cells

MDR

Multidrug resistance

SP

Side population

Notes

Acknowledgments

We would like acknowledge the support from United States Department of Defense Prostate Cancer Research Program Pre-doctoral Fellowship Award W81XWH-10-1-0636 (M.T.W, H.J.), Breast Cancer Research Program Idea Award W81XWH-08-1-0540 (D.N.), and National Cancer Institute R01CA13445 (D.N.) and R15CA133776 (D.N.).

Conflicts of Interest

No potential conflicts of interest were disclosed.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Man-Tzu Wang
    • 1
  • Hongmei Jiang
    • 1
  • Debasish Boral
    • 1
  • Daotai Nie
    • 1
  1. 1.Department of Medical Microbiology, Immunology, and Cell BiologySouthern Illinois University School of Medicine and Simmons Cancer InstituteSpringfieldUSA

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