Atlas of Soft Tissue Tumor Pathology pp 17-22 | Cite as
Chondroid and Osseous Tumors of Soft Tissue
Abstract
Cartilage and bone formation may be found in several types of soft tissue tumor, either as a metaplastic phenomenon or as a neoplastic component of some sarcomas. Metaplastic (benign) osteochondroid change may occur in hamartomas; benign neoplasms such as lipoma, fibromatosis, and calcifying aponeurotic fibroma; and the stroma in malignant soft tissue tumors, including liposarcoma, synovial sarcoma, low-grade fibromyxoid sarcoma, and sclerosing epithelioid fibrosarcoma. Malignant cartilage or bone formation also may occur by divergent differentiation or as heterologous mesenchymal elements in müllerian and other carcinosarcomas, mesotheliomas, malignant peripheral nerve sheath tumors, and dedifferentiated liposarcomas.
Keywords
Synovial Sarcoma Soft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Benign Neoplasm Cartilaginous TumorSuggested Reading
- Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, et al. Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases. Cancer. 1990;65:2762–70.PubMedCrossRefGoogle Scholar
- Bansal M, Goldman AB, DiCarlo EF, McCormack R. Soft tissue chondromas: diagnosis and differential diagnosis. Skeletal Radiol. 1993;22:309–15.PubMedCrossRefGoogle Scholar
- Chaudhry IH, Kazakov DV, Michal M, Mentzel T, Luzar B, Calonje E. Fibro-osseous pseudotumor of the digit: a clinicopathological study of 17 cases. J Cutan Pathol. 2010;37:323–9.PubMedCrossRefGoogle Scholar
- Davis RI, Hamilton A, Biggart JD. Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potential. Hum Pathol. 1998;29:683–8.PubMedCrossRefGoogle Scholar
- Dupree WB, Enzinger FM. Fibro-osseous pseudotumor of the digits. Cancer. 1986;58:2103–9.PubMedCrossRefGoogle Scholar
- Guccion JG, Font RL, Enzinger FM, Zimmerman LE. Extraskeletal mesenchymal chondrosarcoma. Arch Pathol. 1973;95:336–40.PubMedGoogle Scholar
- Humphreys S, Pambakian H, McKee PH, Fletcher CD. Soft tissue chondroma–a study of 15 tumours. Histopathology. 1986;10:147–59.PubMedCrossRefGoogle Scholar
- Patel RM, Weiss SW, Folpe AL. Heterotopic mesenteric ossification: a distinctive pseudosarcoma commonly associated with intestinal obstruction. Am J Surg Pathol. 2006;30:119–22.PubMedCrossRefGoogle Scholar
- Shakked RJ, Geller DS, Gorlick R, Dorfman HD. Mesenchymal chondrosarcoma: clinicopathologic study of 20 cases. Arch Pathol Lab Med. 2012;136:61–75.PubMedCrossRefGoogle Scholar
- Wang L, Motoi T, Khanin R, Olshen A, Mertens F, Bridge J, et al. Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. Genes Chromosomes Cancer. 2012;51:127–39.PubMedCrossRefGoogle Scholar
- Wehrli BM, Huang W, De Crombrugghe B, Ayala AG, Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol. 2003;34:263–9.PubMedCrossRefGoogle Scholar