Endoscopic Tools/Techniques for Tissue Sampling

  • Daniel von Renteln
  • Melina C. VassiliouEmail author


In 1932, the semiflexible endoscope was developed by Rudolph Schindler, thus permitting endoscopic inspection of the stomach. A modification in 1938 allowed photo-documentation and introduced a working channel through which biopsies could be performed. The first fully flexible endoscope was then introduced in 1957 by Basil Hirschowitz. These developments set the foundation for modern gastrointestinal endoscopy. The flexible endoscope is now an indispensable tool for the visualization and diagnosis of inflammatory, infectious, premalignant and malignant gastrointestinal diseases. Endoscopic tissue sampling is an essential part of the diagnostic process and permits histopathologic evaluation of lesions detected by endoscopy. This chapter reviews tools and techniques for endoscopic tissue sampling. Image-enhanced techniques such as virtual histology and recommended biopsy and screening protocols for the most common gastrointestinal pathologies are also discussed.


Optical Coherence Tomography Celiac Disease Endoscopic Mucosal Resection Narrow Band Imaging Eosinophilic Esophagitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

Video 7.1

EUS-FNA using the ProCore needle (M4V 9199 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Interdisciplinary EndoscopyUniversity Hospital, University Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Department of SurgeryMontreal General Hospital, McGill UniversityMontrealCanada

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