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The CD28/B7 Pathway: A Novel Regulator of Plasma Cell Function

  • Modesta N. Njau
  • Joshy Jacob
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 785)

Abstract

The CD28/B7 pathway is pivotal for the activation, optimal function, and regulation of T cell function. While the CD28 receptor and its ligands B7.1/B7.2 are also expressed on plasma cells, little is known of the role of the CD28/B7 pathway in plasma cell function. In this chapter we discuss the recent studies that have examined the role of CD28 expression on plasma cell function. Both stimulatory and inhibitory effects of CD28 on plasma cells have been reported. Based on our findings we propose that under homeostatic conditions the CD28/B7 interaction mediates regulation of plasma cell function whereas during inflammation this pathway can be perturbed to ramp up Ab production from existing plasma cells.

Keywords

Plasma cells CD28 B cells Antibody CD28/B7 

Abbreviations

Abs

Antibodies

PD

Programmed death

PDL

Programmed death ligand

BAFF

B cell activating factor

BAFF-R

B cell activating factor receptor

APRIL

A proliferation-inducing ligand

TACI

Transmembrane activator, calcium modulator, and cyclophilin ligand interactor

NOD

Non-obese diabetic mice

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate CenterEmory UniversityAtlantaUSA

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