Kisspeptin and Puberty in Mammals

  • Ei Terasawa
  • Kathryn A. Guerriero
  • Tony M. Plant
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 784)

Abstract

Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel hypothesis for the role of kisspeptin signaling in the onset of this crucial developmental event. According to this hypothesis, although kisspeptin neurons in the arcuate nucleus (ARC) are critical for puberty, this is simply because these cells are an integral component of the hypothalamic GnRH pulse generating mechanism that drives intermittent release of the decapeptide, as an increase in GnRH is obligatory for the onset of puberty. In our model, ARC kisspeptin neurons play no “regulatory” role in controlling the timing of puberty. Rather, as a component of the neural network responsible for GnRH pulse generation, they subserve upstream regulatory mechanisms that are responsible for the timing of puberty.

Abbreviations

ARC

Arcuate nucleus

AVPV

Anteroventral periventricular nucleus

E2

Estradiol

ERα

Estrogen receptor alpha

GABA

γ-Aminobutyric acid IPI Inter-pulse interval

KISS1

Kisspeptin gene (primates)

Kiss1

Kisspeptin gene (non-primates)

KISS1R

Kisspeptin-1 receptor (primates)

Kiss1r

Kisspeptin-1 receptor (non-primates)

KP

Kisspeptin

MBH

Medial basal hypothalamus

ME

Median eminence

S-ME

Stalk-median eminence

NPY

Neuropeptide Y

POA

Preoptic area

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Ei Terasawa
    • 1
  • Kathryn A. Guerriero
    • 1
  • Tony M. Plant
    • 2
  1. 1.Wisconsin National Primate Research CenterUniversity of WisconsinMadisonUSA
  2. 2.University of Pittsburgh School of MedicinePittsburghUSA

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