Small-Cell Lung Cancer: An Update on Targeted Therapies

Chapter
Part of the Advances in Experimental Medicine and Biology book series (volume 779)

Abstract

Lung cancer is the leading cause of cancer-related deaths world-wide and small-cell lung cancer (SCLC) accounts for up to 25% of lung cancer deaths. There has been a considerable amount of research in the understanding of the depth of biology of SCLC and utilizing this knowledge to develop targeted approaches. The treatment of SCLC remains a challenge, despite remarkable initial efficacy to combination chemotherapy and radiation therapy. The response is usually short-lived and the prognosis of SCLC has not changed over the past few decades, necessitating the critical need for evaluating novel agents/therapies. Several signaling pathways have been found to be activated in SCLC tumor cells, forming a rationale for blocking some of the drugable targets. Molecular changes and biological markers have been identified but remain to be validated. Novel and targeted agents have been evaluated but without much success. Increasing understanding of the biology and potential clinical evaluation of biomarkers will pave the way for more effective treatments.

Keywords

Small cell lung cancer Keratin Etoposide Topotecan Irinotecan Docetaxel Gemcitabine 3p21.3 RASSFIA myc NFkB c-Met HGF VEGF IGF-1 GRP FRAP Thalidomide Carboplatin Bevacizumab Cisplatin Sorafenib Cediranib Vandetanib Aflibercept c-kit EGFR TKI bcr-abl Imatinib Gefitinib mTOR Everolimus Ganitumab Dasatinib Obatoclax HDAC inhibitor Hedgehog inhibitor Bendamustine Ifosfamide Circulating tumor cells 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Monika Joshi
    • 1
  • Ayodele Ayoola
    • 1
  • Chandra P. Belani
    • 1
  1. 1.Department of MedicinePenn State Hershey Medical CenterHersheyUSA

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