Applications of Electrochemistry in Medicine

Chapter
First Online:
Part of the Modern Aspects of Electrochemistry book series (MAOE, volume 56)

Abstract

Medicine is an applied field of science that has always strived to make use of new and existing technologies and techniques, such as the synthesis of medications, X-ray and magnetic resonance (MR) imaging, mechanical implants, along with a host of others, to improve the health and increase the life span of individuals. Advancements in medicine have largely occurred in concert with technological advances resulting in a sophisticated interplay in the advancement of both. The ongoing goal of medicine to better treat patients requires a great deal of research from a wide variety of fields including electrochemistry.

Keywords

Bioactive Glass Orthopedic Implant Hydroxyapatite Coating Stent Coating Biocompatible Coating 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. 1.
    Reclaru L, Lerf R, Eschler P-Y, Meyer J-M. Corrosion behavior of a welded stainless-steel orthopedic implant. Biomaterials. 2001;22:269–79.CrossRefGoogle Scholar
  2. 2.
    Reclaru L, Lerf R, Eschler P-Y, Blatter A, Meyer J-M. Pitting, crevice and galvanic corrosion of REX stainless-steel/CoCr orthopedic implant material. Biomaterials. 2002;23:3479–85.CrossRefGoogle Scholar
  3. 3.
    Zardiackas L, Roach M, Disegi J (2005) Galvanic corrosion of cobalt-base and titanium-base implant material couples. Medical device, materials II: proceedings from the materials & processes for medical devices conference 2004, p 398–402Google Scholar
  4. 4.
    Sawyer PN, Pate JW. Electrical potential differences across the normal aorta and aortic grafts of dogs. Am J Physiol. 1953;175:113.Google Scholar
  5. 5.
    Sawyer PN, Dennis C, Wesolowski SA. Electrical hemostasis in uncontrollable bleeding states. Ann Surg. 1961;154:556.CrossRefGoogle Scholar
  6. 6.
    Sawyer PN. Application of electrochemical techniques to the solution of problems in medicine. J EIectrochem Soc. 1978;125(10):419C–36C.CrossRefGoogle Scholar
  7. 7.
    Alvarez E, Vinciguerra J, DesJardins JD. The effect of a novel CoCr electropolishing technique on CoCr-UHMWPE bearing frictional performance for total joint replacements. Tribol Int. 2012;47:204–11.CrossRefGoogle Scholar
  8. 8.
    Witte F. The history of biodegradable magnesium implants: a review. Acta Biomater. 2010;6:1680–92.CrossRefGoogle Scholar
  9. 9.
    Xue D, Yun Y, Tan Z, Dong Z, Schulz MJ. In vivo and in vitro degradation behavior of magnesium alloys as biomaterials. J Mater Sci Tech. 2012;28(3):261–7.CrossRefGoogle Scholar
  10. 10.
    An YH, Woolf SK, Friedman RJ. Pre-clinical in vivo evaluation of orthopaedic bioabsorbable devices. Biomaterials. 2000;21:2635–52.CrossRefGoogle Scholar
  11. 11.
    Ylikontiola L, Sundqvuist K, Sàndor GKB, Törmälä P, Ashammakhi N. Self-reinforced bioresorbable poly-L/DL-lactide [SR-P(L/DL)LA] 70/30 miniplates and miniscrews are reliable for fixation of anterior mandibular fractures: a pilot study. Oral Surg Oral Med Oral Pathol. 2004;97(3):312–7.CrossRefGoogle Scholar
  12. 12.
    Suzuki H. Advances in the microfabrication of electrochemical sensors and systems. Electroanalysis. 2000;12(9):703–15.CrossRefGoogle Scholar
  13. 13.
    Skladal P. Advances in electrochemical immunosensors. Electroanalysis. 1997;9(10):737–45.CrossRefGoogle Scholar
  14. 14.
    Ahmed MU, Hossain MM, Tamiya E. Electrochemical biosensors for medical and food applications. Electroanalysis. 2008;20(6):616–26.CrossRefGoogle Scholar
  15. 15.
    Qi Y, McAlpine MC. Nanotechnology-enabled flexible and biocompatible energy harvesting. Energ Environ Sci. 2010;3(9):1275–85.CrossRefGoogle Scholar
  16. 16.
    Häsler E, Stein L, Harbauer G. Implantable physiological power supply with PVDF film. Ferroelectrics. 1984;60:277–82.CrossRefGoogle Scholar
  17. 17.
    Park KI, Xu S, Liu Y, Hwang GT, Kang SJ, Wang ZL, Lee KJ. Piezoelectric BaTiO3 thin film nanogenerator on plastic substrates. Nano Lett. 2010;10:4939–43.CrossRefGoogle Scholar
  18. 18.
    Li Z, Zhu GA, Yang RS, Wang AC, Wang ZL. Muscle-driven in vivo nanogenerator. Adv Mater. 2010;22(23):2534–7.CrossRefGoogle Scholar
  19. 19.
    Zhu G, Yang R, Wang S, Wang ZL. Flexible high-output nanogenerator based on lateral ZnO nanowire array. Nano Lett. 2010;10:3151–5.CrossRefGoogle Scholar
  20. 20.
    Gilanyi M, Ikrényi C, Fekete J, Ikrényi K, Kovach AGB. Ion concentrations in subcutaneous interstitial fluid: measured versus expected values. Am J Physiol. 1988;255(3):F513–9.Google Scholar
  21. 21.
    Gotman I. Characteristics of metals used in implants. Journal of Endourology 1997;11(6):383-389Google Scholar
  22. 22.
    Biesiekierski A, Wang J, Abdel-Hady Gepreel M, Wen C. A new look at biomedical Ti-based shape memory alloys. Acta Biomater. 2012;8:1661–9.CrossRefGoogle Scholar
  23. 23.
    Walkowiak-Przybyło M, Klimek L, Okrόj W, Jakubowski W, Chwiłka M, Czajka A, Walkowiak B. Adhesion, activation, and aggregation of blood platelets and biofilm formation on the surfaces of titanium alloys Ti6Al4V and Ti6Al7Nb. J Biomed Mater Res A. 2012;100A(3):768–75.CrossRefGoogle Scholar
  24. 24.
    Aguilar Maya AE, Grana DR, Hazarabedian A, Kokubu GA, Luppo MI, Vigna G. Zr–Ti–Nb porous alloys for biomedical application. Mater Sci Eng C. 2012;32:321–9.CrossRefGoogle Scholar
  25. 25.
    Lecoeur J, Viegas MF, Abrantes LM. Metal materials biodegradation: a chronoamperometric study. J Mater Sci Mater Med. 1990;1:105–9.Google Scholar
  26. 26.
    Mani G, Feldman MD, Patel D, Agrawal CM. Coronary stents: a materials perspective. Biomaterials 2007;28:1689–1710Google Scholar
  27. 27.
    Plecko M, Sievert C, Andermatt D, Frigg R, Kronen P, Klein K, Stübinger S, Nuss K, Bürki A, Ferguson S, Stoeckle U, von Rechenberg B. Osseointegration and biocompatibility of different metal implants—a comparative experimental investigation in sheep. BMC Musculoskelet Disord. 2012;13:32.CrossRefGoogle Scholar
  28. 28.
    Williams DF. Titanium and titanium alloys. In: Williams DF, editor. Biocompatibility of clinical implant materials, vol. II. Boca Raton, FL: CRC Press; 1981. p. 9–44.Google Scholar
  29. 29.
    Williams DF. Tissue-biomaterial interactions. Journal of Materials Science. 1987;22:3421–3445Google Scholar
  30. 30.
    Assad M, Lemieux N, Rivard CH, Yahia L’H. Comparative in vitro biocompatibility of nickel-titanium, pure nickel, pure titanium, and stainless steel: genotoxicity and atomic absorption evaluation. Bio-Med Mater Eng. 1999;9:1–12.Google Scholar
  31. 31.
    Nygren H, Tengvall P, Lundström I. The initial reactions of TiO2 with blood. J Biomed Mater Res. 1997;34:487–92.CrossRefGoogle Scholar
  32. 32.
    Bai Z, Filiaggi MJ, Dahn JR. Fibrinogen adsorption onto 316L stainless steel, Nitinol and titanium. Surf Sci. 2009;603:839–46.CrossRefGoogle Scholar
  33. 33.
    Gettens RTT, Gilbert JL. Fibrinogen adsorption onto 316L stainless steel under polarized conditions. J Biomed Mater Res. Part A 2008;85(1):176–187Google Scholar
  34. 34.
    Kereiakes DJ, Cannon LA, Ormiston JA, Turco MA, Mann T, Mishkel GJ, McGarry T, Wang H, Underwood P, Dawkins KD. Propensity-matched patient-level comparison of the TAXUS Liberté and TAXUS element (ION) paclitaxel-eluting stents. Am J Cardiol. 2011;108(6):828–37.CrossRefGoogle Scholar
  35. 35.
    Duda SH, Wiskirchen J, Tepe G, Bitzer M, Kaulich TW, Stoeckel D, Claussen CD. Physical properties of endovascular stents: an experimental comparison. J Vasc Intervent Radiol. 2000;11(5):645–54.CrossRefGoogle Scholar
  36. 36.
    Gertner ME, Schlesinger M. Electrochem and Solid-State Letters, 2003;6(4): J4–6.CrossRefGoogle Scholar
  37. 37.
    Sàndor GKB. Branemark’s remarkable implant: dentistry’s quantum leap—the surgical perspective. Geriatr Med Quart. 1989;1:162–7.Google Scholar
  38. 38.
    Reiner T, Kababya S, Gotman I. Protein incorporation within Ti scaffold for bone ingrowth using Sol–gel SiO2 as a slow release carrier. J Mater Sci Mater Med. 2008;19:583–9.CrossRefGoogle Scholar
  39. 39.
    Malluche HH. Aluminium and bone disease in chronic renal failure. Nephrol Dial Transplant. 2002;17(2):21–4.CrossRefGoogle Scholar
  40. 40.
    Matsuno H, Yokoyama A, Watari F, Uo M, Kawasaki T. Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium. Biomaterials. 2001;22:1253-1262Google Scholar
  41. 41.
    Niinomi M. Recent metallic materials for biomedical applications. Metall Mater Trans A. 2002;33(3):477–86.CrossRefGoogle Scholar
  42. 42.
    Seeherman H. The influence of delivery vehicles and their properties on the repair of segmental defects and fractures with osteogenic factors. Journal of Bone & Joint Surgery. 2001;83(Supp 1):S79.Google Scholar
  43. 43.
    Liu Y, Li JP, Hunziker EB, De Groot K. Incorporation of growth factors into medical devices via biomimetic coatings. Phil Trans R Soc A. 2006;364(1838):233–48.CrossRefGoogle Scholar
  44. 44.
    Serlo WS, Ylikontiola L, Vesala A-L, Kaarela OI, Iber T, Sàndor GKB, Ashammakhi N. Effective correction of frontal cranial deformities using biodegradable fixation on the inner surface of the cranial bones during infancy. Childs Nerv Syst. 2007;23:1439–45.CrossRefGoogle Scholar
  45. 45.
    Poncin P, Proft J. Stent Tubing: Understanding the Desired Attributes. 2004. Materials & processes from medical devices conference, Anaheim, CA, USA, 8–10 Sept 2003, p 253–259Google Scholar
  46. 46.
    Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006;27:1728–34.CrossRefGoogle Scholar
  47. 47.
    Song GL, Song S. A possible biodegradable magnesium implant material. Adv Eng Mater. 2007;9(4):298–302.CrossRefGoogle Scholar
  48. 48.
    Song GL. Control of biodegradation of biocompatable magnesium alloys. Corros Sci. 2007;49:1696–701.CrossRefGoogle Scholar
  49. 49.
    Yun YH, Dong ZY, Yang D, Schulz MJ, Shanov VN, Yarmolenko S, Xu Z, Kumta P, Sfeir C. Biodegradable Mg corrosion and osteoblast cell culture studies. Mater Sci Eng C. 2009;29:1814–21.CrossRefGoogle Scholar
  50. 50.
    Gu XN, Zheng YF, Cheng Y, Zhong SP, Xi TF. In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials. 2009;30(4):484–98.CrossRefGoogle Scholar
  51. 51.
    Walker J, Shadanbaz S, Kirkland NT, Stace E, Woodfield T, Staiger MP, Dias GJ. Magnesium alloys: predicting in vivo corrosion with in vitro immersion testing. J Biomed Mater Res B Appl Biomater. 2012;100B(4):1134–41.CrossRefGoogle Scholar
  52. 52.
    Zhang J, Gu Y, Guo Y, Ning C. Electrochemical behavior of biocompatible AZ31 magnesium alloy in simulated body fluid. J Mater Sci. 2012;47:5197–204.CrossRefGoogle Scholar
  53. 53.
    Yao C, Slamovich EB, Webster TJ. Enhanced osteoblast functions on anodized titanium with nanotube-like structures. J Biomed Mater Res A. 2008;85A(1):157–66.CrossRefGoogle Scholar
  54. 54.
    Hehrlein C, Zimmermann M, Metz J, Ensigner W, Kubler W. Influence of surface texture and charge on the biocompatibility of endovascular stents. Coron Artery Dis. 1995;6(7):581–6.Google Scholar
  55. 55.
    Severini A, Mantero S, Tanzi MC, Cigada A, Salvetti M, Cozzi G, Motta A. Polyurethane-coated, self-expandable biliary stent: an experimental study. Acad Radiol. 1995;2(12):1078–81.CrossRefGoogle Scholar
  56. 56.
    Whelan DM, van der Giessen WJ, Krabbendam SC, van Vliet EA, Verdouw PD, Serruys PW, van Beusekom HMM. Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries. Heart. 2000;83:338–45.CrossRefGoogle Scholar
  57. 57.
    Giannakopoulos HE, Sinn DP, Quinn PD. Biomet microfixation temporomandibular joint replacement system: a 3-year follow-up study of patients treated during 1995 to 2005. J Oral Maxillofac Surg. 2012;70(4):787–94.CrossRefGoogle Scholar
  58. 58.
    Vercaigne S, Wolke JGC, Naert I, Jansen JA. Histomorphometrical and mechanical evaluation of titanium plasma-spray-coated implants placed in the cortical bone of goats. J Biomed Mater Res. 1998;41(1):41–8.CrossRefGoogle Scholar
  59. 59.
    Oh S, Daraio C, Chen L-H, Pisanic TR, Fiñones RR, Jin S. Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes. J Biomed Mater Res A. 2006;78A(1):97–103.CrossRefGoogle Scholar
  60. 60.
    Yu W, Zhang Y, Xu L, Sun S, Jiang X, Zhang F. Microarray-based bioinformatics analysis of osteoblasts on TiO2 nanotube layers. Colloids Surf B Biointerfaces. 2012;93:135–42.CrossRefGoogle Scholar
  61. 61.
    De Lange GL, Donath K. Interface between bone tissue and implants of solid hydroxyapatite or hydroxyapatite-coated titanium implants. Biomaterials. 1989;10(2):121–5.CrossRefGoogle Scholar
  62. 62.
    Ripamonti U, Roden LC, Renton LF. Osteoinductive hydroxyapatite-coated titanium implants. Biomaterials. 2012;33:3813–23.CrossRefGoogle Scholar
  63. 63.
    Grandfield K, Palmquist A, Gonçalves S, Taylor A, Taylor M, Emanuelsson L, Thomsen P, Engqvist H. Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction. J Mater Sci Mater Med. 2011;22:899–906.CrossRefGoogle Scholar
  64. 64.
    Hench LL. Biomaterials: a forecast for the future. Biomaterials. 1998;19:1419–23.CrossRefGoogle Scholar
  65. 65.
    Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, Datta BK, Mandal TK, Basu D, Bhattacharya RN. Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial. Pharm Res. 2010;27:1659–76.CrossRefGoogle Scholar
  66. 66.
    Gravens DL, Margraf HW, Butcher HR, Ballinge WF. The antibacterial effect of treating sutures with silver. Surgery. 1973;73(1):122–7.Google Scholar
  67. 67.
    Pollini M, Paladini F, Licciulli A, Maffezzoli A, Nicolais L, Sannino A. Silver-coated wool yarns with durable antibacterial properties. J Appl Polymer Sci. 2012;125(3):2239–44.CrossRefGoogle Scholar
  68. 68.
    Roy M, Fielding GA, Beyenal H, Bandyopadhyay A, Bose S. Mechanical, in vitro antimicrobial, and biological properties of plasma-sprayed silver-doped hydroxyapatite coating. ACS Appl Mater Interfaces. 2012;4:1341–9.CrossRefGoogle Scholar
  69. 69.
    Massè A, Bruno A, Bosetti M, Biasibetti A, Cannas M, Gallinaro P. Prevention of pin track infection in external fixation with silver coated pins: clinical and microbiological results. J Biomed Mater Res. 2000;53(5):600–4.CrossRefGoogle Scholar
  70. 70.
    Bosetti M, Massè A, Tobin E, Cannas M. Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity. Biomaterials. 2002;23:887–92.CrossRefGoogle Scholar
  71. 71.
    Mahan J, Seligson D, Henry S, Hynes P, Dobbins J. Factors in pin tract infections. Orthopedics. 1991;14:305–8.Google Scholar
  72. 72.
    Martínez-Gutierrez F, Thi EP, Silverman JM, de Oliveira CC, Svensson SL, Vanden Hoek A, Sánchez EM, Reiner NE, Gaynor EC, Pryzdial ELG, Conway EM, Orrantia E, Ruiz F, Av-Gay Y, Bach H. Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine. 2012;8:328–36.CrossRefGoogle Scholar
  73. 73.
    Petro R, Schlesinger M. Direct electroless deposition of nickel boron alloys and copper on aluminum containing magnesium alloys. Electrochem Solid State Lett. 2011;14(4):D37–40.CrossRefGoogle Scholar
  74. 74.
    Petro R, Schlesinger M. Direct electroless deposition of low phosphorous Ni-P films on AZ91D Mg alloy. J Electrochem Soc. 2012;159(7):D455–61.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PhysicsUniversity of WindsorWindsorCanada

Personalised recommendations