Taurine 8 pp 427-435

Synergistic Effects of Taurine and l-Arginine on Attenuating Insulin Resistance Hypertension

  • Ying Feng
  • Jitao Li
  • Jiancheng Yang
  • Qunhui Yang
  • Qiufeng Lv
  • Yongchao Gao
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

To elucidate the synergistic effects of taurine and l-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% l-arginine, 2.1% taurine + 0.9% l-arginine, 1.5% taurine + 1.5% l-arginine and 3% l-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and l-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and l-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and l-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and l-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.

Abbreviations

SBP

Systolic blood pressure

Ins

Insulin

ET

Endothelin

cGMP

Cyclic guanosine monophosphate

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ying Feng
    • 1
  • Jitao Li
    • 1
  • Jiancheng Yang
    • 1
  • Qunhui Yang
    • 1
  • Qiufeng Lv
    • 1
  • Yongchao Gao
    • 1
  • Jianmin Hu
    • 1
  1. 1.College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangP.R. China

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